Chemiluminescent probes in cancer biology

被引：29
作者：
Rachel Blau
Omri Shelef
Doron Shabat
Ronit Satchi-Fainaro
机构：
[1] Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv
[2] Department of NanoEngineering, University of California, San Diego, La Jolla, CA
[3] Department of Organic Chemistry, School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv
[4] Sagol School of Neuroscience, Tel Aviv University, Tel Aviv
来源：
Nature Reviews Bioengineering | 2023年 / 1卷 / 9期
基金：
欧盟地平线“2020”; 欧洲研究理事会; 以色列科学基金会;
关键词：
D O I：
10.1038/s44222-023-00074-0
中图分类号：
学科分类号：
摘要：
Optical imaging technologies that use fluorescence and chemiluminescence probes allow the real-time detection of biological activity in the context of location, time and environment. Optical imaging is particularly important for the diagnosis and investigation of cancer. Chemiluminescence is based on the production of an electronically excited species from reactants followed by the release of visible light. Unlike fluorescence imaging, chemiluminescence does not require light excitation and is thus not limited by autofluorescence and high background signals. In this Review, we discuss the four main types of chemiluminescent probes, that is, luminol and its derivatives, peroxalate esters, phenoxy-1,2-dioxetanes with light emission through energy transfer and phenoxy-1,2-dioxetanes with direct light emission, highlighting their design, mode of action, compatibility and applications in cancer biology, diagnosis and treatment. We outline how these chemiluminophores can act as single-component probes for the in vivo and in vitro detection and imaging of various analytes and enzymes and highlight applications that may benefit from chemiluminescent imaging probes. © Springer Nature Limited 2023.
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页码：648 / 664
页数：16
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