Monitoring the fluidized bed granulation process based on S-statistic analysis of a pressure time series

被引:1
作者
Chaplin G. [1 ]
Pugsley T. [1 ]
Winters C. [2 ]
机构
[1] Department of Chemical Engineering, The University of Saskatchewan, Saskatoon, Sask. S7N 5C5
[2] Merck and Co. Inc., West Point
基金
加拿大自然科学与工程研究理事会;
关键词
Chaos; Fluidized bed; Granulation; Hydrodynamics; Pressure fluctuations; S-statistic;
D O I
10.1208/pt060229
中图分类号
学科分类号
摘要
Pressure fluctuation measurements collected during the fluidized bed granulation of pharmaceutical granule have been analyzed using the attractor comparison technique denoted as the S-statistic. Divergence of the bed state from the reference during granulation is followed by a return to a condition statistically similar to the original state of the dry fluidized ingredients on drying. This suggests insensitivity of the S-statistic technique to the changes in particle size distribution occurring during the granulation process. Consequently, the monitoring of pressure fluctuations alone may provide an easily implemented technique for the tracking of granule moisture and process end-point determination. Copyright ©2003. All Rights Reserved.
引用
收藏
页码:E198 / E201
页数:3
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