A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines

Duncan GS(2012)2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation Proc Natl Acad Sci U S A 109 21034-9

Brenner D(2005)A ring substantiated estrogen-3-O-sulfamates: potent multitargeted anticancer agents J Med Chem 48 5243-56

Tusche MW(2011)Docking, synthesis, and in vitro evaluation of antimitotic estrone analogues Chem Biol Drug Des 77 173-81

Brüstle A(2010)Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3- 17-O, O-bis-sulfamate J Med Chem 53 2942-51

Knobbe CB(2004)Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents Br J Cancer 90 932-7

Elia AJ(2011)Synthesis of 2-substitued 17β-hydroxy/17-methylene estratrienes and their in vitro cytotoxicity in human cancer cell cultures Steroids 76 1491-504

Leese MP(2012)In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity Plos One 7 e52205-85

Hejaz MAM(2013)Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells Plos One 8 e53853-81

Newman SP(2012)Sulphamoylated estradiol analogue induces antiproliferative activity and apoptosis in breast cell lines Cell Mol Biol Lett 17 549-22

Purohit A(2011)In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells Cell Prolif 44 567-42

Duncan GS(2012)2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation Proc Natl Acad Sci U S A 109 21034-9

Brenner D(2005)A ring substantiated estrogen-3-O-sulfamates: potent multitargeted anticancer agents J Med Chem 48 5243-56

Tusche MW(2011)Docking, synthesis, and in vitro evaluation of antimitotic estrone analogues Chem Biol Drug Des 77 173-81

Brüstle A(2010)Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3- 17-O, O-bis-sulfamate J Med Chem 53 2942-51

Knobbe CB(2004)Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents Br J Cancer 90 932-7

Elia AJ(2011)Synthesis of 2-substitued 17β-hydroxy/17-methylene estratrienes and their in vitro cytotoxicity in human cancer cell cultures Steroids 76 1491-504

Leese MP(2012)In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity Plos One 7 e52205-85

Hejaz MAM(2013)Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells Plos One 8 e53853-81

Newman SP(2012)Sulphamoylated estradiol analogue induces antiproliferative activity and apoptosis in breast cell lines Cell Mol Biol Lett 17 549-22

Purohit A(2011)In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells Cell Prolif 44 567-42