Biological Effect of the Surface Modification of the Fibrous Poly(L-lactic acid) Scaffolds by Radio Frequency Magnetron Sputtering of Different Calcium-Phosphate Targets

被引：18

作者：

Goreninskii S.I. ^{[1
]}

Bogomolova N.N. ^{[2
]}

Malchikhina A.I. ^{[2
]}

Golovkin A.S. ^{[3
]}

Bolbasov E.N. ^{[2
]}

Safronova T.V. ^{[4
]}

Putlyaev V.I. ^{[4
]}

Tverdokhlebov S.I. ^{[2
]}

机构：

[1] The Department of Biotechnology and Organic Chemistry, National Research Tomsk Polytechnic University, 30 Lenin av., Tomsk

[2] The Department of Experimental Physics, National Research Tomsk Polytechnic University, 30 Lenin av., Tomsk

[3] Federal Almazov Medical Research Centre, 2 Akkuratova st., St. Petersburg

[4] The Chemistry Department, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow

来源：

BioNanoScience | 2017年 / 7卷 / 1期

基金：

俄罗斯科学基金会;

关键词：

Biomaterial; Calcium-phosphate; Magnetron sputter deposition; Poly(lactic) acid; Scaffold; Surface modification;

D O I：

10.1007/s12668-016-0383-x

中图分类号：

学科分类号：

摘要：

Biodegradable materials, in particular poly(L-lactic acid), are widely used in medicine and tissue engineering. Electrospinning is one of the most promising methods for the fabrication of scaffolds for tissue and organ regeneration. Due to their fibrous structure, high surface-to-volume ratio and great adjustability of electrospinning parameters such scaffolds are able to mimic the topology of the extracellular matrix (ECM) of a native human tissue. This paper demonstrates the effect of radio frequency magnetron sputtering (RFMS) modification of the poly(L-lactic acid) fibrous scaffolds on their structure and cell adhesion and proliferation. RFMS modification was performed using four different targets: hydroxyapatite (HAP), tricalcium phosphate (TCP), amorphous calcium pyrophosphate (CPP) and dicalcium phosphate dihydrate (DCPD). Biodegradable fibrous materials with maximum Ca/P ratio on the surface at 0.542 were obtained. It was observed that prolonged time of the treatment leads to destruction of the fibers on the surface layer of the scaffold. Moreover, we have indicated that all obtained materials demonstrate cytotoxic activity due to the formation of the toxic compounds on the material surface. © 2017, Springer Science+Business Media New York.

引用

页码：50 / 57

页数：7

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