Synthesis of new Di-, Tetra-, and hexahydropyrazolo[3,4-e][1,4]diazepine derivatives

被引：0
作者：
A. V. Bol’but
S. V. Kemskii
M. V. Vovk
机构：
[1] National Academy of Sciences of Ukraine,Institute of Organic Chemistry
来源：
Russian Journal of Organic Chemistry | 2012年 / 48卷
关键词：
Diazepine; Oxoethyl; Pyrazolopyrimidine; Diazepine Ring; Ethoxycarbonylmethyl;
D O I：
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学科分类号：
摘要：
Alkaline hydrolysis of 5-(2,2-diethoxyethyl-, aroylmethyl-, or ethoxycarbonylmethyl)-1H-pyrazolo-[3,4-e]pyrimidin-4(5H)-ones gave 5-amino-N-(2,2-diethoxyethyl-, aroylmethyl-, or carboxymethyl)-1H-pyrazole-4-carboxamides which underwent cyclization to the corresponding 7-hydroxy-5,6,7,8-tetrahydropyrazolo-[3,4-e][1,4]diazepin-4(1H)-ones, 5,6-dihydropyrazolo[3,4-e][1,4]diazepin-4(1H)-ones, and 1,5,6,8-tetrahydropyrazolo[3,4-e][1,4]diazepine-4,7-diones. Reduction of the cyclization products with NaBH4 and LiAlH4 afforded 5,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-4(1H)-ones and 1,4,5,6,7,8-hexahydropyrazolo[3,4-e]-[1,4]diazepines.
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页码：991 / 1002
页数：11
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