Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

被引：0
作者：
Emadeldin Hassanin
Isabel Spier
Dheeraj R. Bobbili
Rana Aldisi
Hannah Klinkhammer
Friederike David
Nuria Dueñas
Robert Hüneburg
Claudia Perne
Joan Brunet
Gabriel Capella
Markus M. Nöthen
Andreas J. Forstner
Andreas Mayr
Peter Krawitz
Patrick May
Stefan Aretz
Carlo Maj
机构：
[1] University Hospital Bonn,Institute for Genomic Statistics and Bioinformatics
[2] University of Luxembourg,Luxembourg Centre for Systems Biomedicine
[3] University of Bonn,Institute of Human Genetics, Medical Faculty
[4] University Hospital Bonn,National Center for Hereditary Tumor Syndromes
[5] European Reference Network on Genetic Tumour Rsik Syndromes (ERNGENTURIS) – Project ID No 739547,Medical Faculty, Institute for Medical Biometry, Informatics and Epidemiology
[6] University Bonn,Hereditary Cancer Program, Catalan Institute of Oncology
[7] Hospitalet de Llobregat,IDIBELL, ONCOBELL
[8] Instituto Salud Carlos III,Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
[9] University Hospital Bonn,Department of Internal Medicine I
[10] Catalan Institute of Oncology-IDBIGI,Hereditary Cancer Program
[11] University of Marburg,Centre for Human Genetics
[12] Research Center Jülich,Institute of Neuroscience and Medicine (INM
来源：
BMC Medical Genomics | / 16卷
关键词：
Colorectal cancer; Family history; Hereditary cancer; Polygenic risk; Risk stratification;
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