Prevalence of GB virus type C in urban Americans infected with human immunodeficiency virus type 1

被引:0
作者
Stephen M Smith
Michael J Donio
Mahender Singh
James P Fallon
Lavanya Jitendranath
Natalia Chkrebtii
Jihad Slim
Diana Finkel
George Perez
机构
[1] Saint Michael's Medical Center,
[2] The New Jersey Medical School,undefined
来源
Retrovirology | / 2卷
关键词
Viremia; Intravenous Drug; Past Infection; Seroconversion;
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摘要
GBV-C virus infection has been linked to improved clinical outcome in HIV-1 co-infected individuals. The epidemiology of GBV-C has, thus far, been limited to the gay male, HIV+ population. Here we describe the prevalence of antibodies against GBV-C envelope glycoprotein E2 and GBV-C viremia in an HIV+ inner city population. This study group is predominantly African-American; 41% of the participants are women. The major risk factor for HIV infection is intravenous drug use. Overall, 56% of the study population had evidence of current or past infection with GBV-C. GBV-C exposure was not associated with hepatitis C virus infection. The group of participants, who had GBV-C viremia and anti-E2 antibodies, had high percentage of patients with an undetectable HIV-1 viral load. These data provide increased insight into the prevalence of GBV-C co-infection in the HIV epidemic in this understudied population.
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