Alpha-Fetoprotein in Retina and Lens of the Human Eye at Early Stages of Prenatal Development

被引：0
作者：
I. G. Panova
Yu. V. Bezzubenko
A. S. Tatikolov
R. A. Poltavtseva
T. Yu. Ivanets
G. T. Sukhikh
机构：
[1] Russian Academy of Sciences,Koltsov Institute of Developmental Biology
[2] Ministry of Public Health of Russia,Kulakov Research Center of Obstetrics, Gynecology and Perinatology
[3] Russian Academy of Sciences,Emanuel Institute of Biochemical Physics
来源：
Journal of Evolutionary Biochemistry and Physiology | 2018年 / 54卷
关键词：
alpha-fetoprotein; human fetus; retina; lens; vitreous body;
D O I：
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学科分类号：
摘要：
The presence of alpha-fetoprotein (AFP) was shown in the retina and lens of the human fetal eye at different stages of prenatal development. PCR analysis revealed AFP mRNA neither in the retina nor in the lens, whereas in the fetal liver (control) AFP mRNA was found to be expressed. The data obtained indicate that AFP is not synthesized in retinal and lens cells of the human fetal eye but is imported from elsewhere to be taken up by these cells. The presence of AFP in the retina and lens implies its involvement in early morphogenesis and differentiation of these ocular tissues during prenatal human development.
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页码：119 / 122
页数：3
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