The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

被引：0
作者：
Hui Guo
Jing Guo
Wenli Xie
Lingqin Yuan
Xiugui Sheng
机构：
[1] Shandong Cancer Hospital Affiliated to Shandong University,Department of Gynecologic Oncology
[2] Shandong Academy of Medical Sciences,School of Medicine and Life Sciences
[3] University of Jinan,undefined
[4] Shandong Academy of Medical Sciences,undefined
[5] Shandong University,undefined
[6] Cancer Hospital Chinese Academy of Medical Sciences,undefined
[7] Shenzhen Center,undefined
来源：
Journal of Ovarian Research | / 11卷
关键词：
Ovarian cancer; 1,25(oh); D; Angiogenesis; Metastasis; Inflammatory; Tumor metabolism; Prevention;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. These results indicate that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer. Consequently, this review describes the epidemiology, molecular mechanism and evidence linking vitamin D deficiency to ovarian cancer.
引用
收藏
相关论文
共 459 条
[21]  
Ong J-S(2017)Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in Northeast China Sci Rep 7 8827-906
[22]  
Cuellar-Partida G(2017)Vitamin D receptor and calcium-sensing receptor polymorphisms and colorectal cancer survival in the Newfoundland population Br J Cancer 117 898-514
[23]  
Lu Y(2006)Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer Am J Prev Med 31 512-1336
[24]  
Fasching PA(2006)Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002 BMC Cancer 6 264-E1023
[25]  
Hein A(2012)Association between ambient ultraviolet radiation and risk of epithelial ovarian cancer Cancer Prev Res (Phila) 5 1330-2571
[26]  
Burghaus S(2012)Prospective study of ultraviolet radiation exposure and risk of cancer in the United States Int J Cancer 131 E1015-943
[27]  
Webb PM(2007)Vitamin D receptor gene polymorphisms and epithelial ovarian cancer risk Cancer Epidemiol Biomark Prev 16 2566-1891
[28]  
de Fazio A(2011)Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the ovarian cancer association consortium Int J Cancer 128 936-216
[29]  
Protani MM(2009)Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies Cancer Res 69 1885-1183
[30]  
Ibiebele TI(2013)Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population J Ovarian Res 6 37-178
12345678910