The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

被引：0
作者：
Hui Guo
Jing Guo
Wenli Xie
Lingqin Yuan
Xiugui Sheng
机构：
[1] Shandong Cancer Hospital Affiliated to Shandong University,Department of Gynecologic Oncology
[2] Shandong Academy of Medical Sciences,School of Medicine and Life Sciences
[3] University of Jinan,undefined
[4] Shandong Academy of Medical Sciences,undefined
[5] Shandong University,undefined
[6] Cancer Hospital Chinese Academy of Medical Sciences,undefined
[7] Shenzhen Center,undefined
来源：
Journal of Ovarian Research | / 11卷
关键词：
Ovarian cancer; 1,25(oh); D; Angiogenesis; Metastasis; Inflammatory; Tumor metabolism; Prevention;
D O I：
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中图分类号：
学科分类号：
摘要：
Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. These results indicate that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer. Consequently, this review describes the epidemiology, molecular mechanism and evidence linking vitamin D deficiency to ovarian cancer.
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