Evaluation of Association between Biomarkers of Lead Exposure in Sardinian Children (Italy)

被引:0
作者
Emanuele Sanna
Alessandro De Micco
Elisabetta Vallascas
机构
[1] University of Cagliari,Anthropological Science Research Unit, Department of Experimental Biology
来源
Biological Trace Element Research | 2011年 / 143卷
关键词
Children; Lead; Blood; Urine; Hair; Environment;
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学科分类号
摘要
The aim of this work is to verify whether there are statistically significant correlations between the concentrations of lead in blood, urine, and hair in children. The sample collected in 2007 consists of 163 children of both sexes from 11–14-year-olds, living in three municipalities of Sardinia (Italy). Inductively coupled plasma atomic mass spectrometry has been used in the determination of lead concentration in biological material. For the overall sample, there is a non-significant partial correlation among the three matrices. However, for subjects with blood lead levels ≥5 μg/dL, there is a significant positive partial correlation between the lead levels in blood and hair, but not between blood and urine or between urine and hair. The results suggest that blood is the preferred biomarker to ascertain lead exposure in human populations, whereas hair can be used as a tool screening when an area is exposed to medium or high lead pollution.
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页码:1383 / 1392
页数:9
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共 173 条
[1]  
Onalaja AO(2000)Genetic susceptibility to lead poisoning Environ Health Perspect 108 S23-S28
[2]  
Claudio L(2008)Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects Arch Toxicol 82 29-36
[3]  
Rezende VB(2003)Release of lead from bone in pregnancy and lactation Environ Res 92 139-151
[4]  
Barbosa F(2007)Lead and δ-aminolevulinic acid dehydratase polymorphism: where does it lead? A meta-analysis Environ Health Perspect 115 35-41
[5]  
Montenegro MF(2008)Environmental lead exposure, maternal thyroid, and childhood growth Environ Res 106 195-202
[6]  
Sandrim CV(1998)Environmental pollution and child health in central and eastern Europe Environ Health Perspect 106 307-311
[7]  
Gerlach RF(1999)Determinants of blood lead levels in Saudi Arabian schoolgirls Int J Occup Environ Health 5 107-114
[8]  
Tanus-Santos JE(2003)Vitamin D receptor Fok1 polymorphism and blood lead concentration in children Environ Health Perspect 111 1665-1669
[9]  
Manton WI(2002)Lead-associated deficits in stature, mental ability and behaviour in children in Karachi Ann Trop Paediatr 22 301-311
[10]  
Angle CR(1999)The Yugoslavia prospective study on environmental lead exposure Environ Health Perspect 107 9-15