Serum Surfactant Protein Levels in Patients Admitted to the Hospital with Acute COPD Exacerbation

被引:0
作者
Andriana I. Papaioannou
Elisavet Konstantelou
Anastasia Papaporfyriou
Konstantinos Bartziokas
Aris Spathis
Petros Bakakos
Stelios Loukides
Nikolaos Koulouris
Spyros Papiris
Konstantinos Kostikas
机构
[1] University of Athens,2nd Respiratory Medicine Department
[2] Attikon Hospital,1st Respiratory Medicine Department
[3] University of Athens,Department of Cytology
[4] Sotiria Hospital,undefined
[5] University of Athens,undefined
[6] Attikon Hospital,undefined
来源
Lung | 2018年 / 196卷
关键词
COPD exacerbations; Surfactant proteins; Lung function; Biomarkers;
D O I
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中图分类号
学科分类号
摘要
Surfactant proteins (SPs) have been studied in COPD patients as biomarkers of disease severity and as predictive factors of unfavorable outcomes. The aim of this exploratory study was to evaluate serum levels of SP-A, SP-B, SP-C, and SP-D in patients with COPD both during AECOPD and in stability and to test their possible associations with disease severity and with the development of new exacerbation events. 20 consecutive COPD patients hospitalized for AECOPD were included. Serum SP levels were measured on admission, at discharge, and on stability. SP-A levels were significantly lower both on admission and at discharge in patients with early relapse compared to those with late or no relapse (29.2 ± 9.1 vs. 43.9 ± 16.9 ng/ml, p = 0.037, and 24.3 ± 2.8 vs. 39.3 ± 14.2 ng/ml, p = 0.011, respectively). SP-B levels were found to have a trend to be higher at discharge and significantly higher on stability in patients experiencing an early relapse compared to those with late or no relapse (52.5 ± 31.6 vs. 31.4 ± 32.3 ng/ml, p = 0.052 and 64.8 ± 32.6 vs. 32.8 ± 25.6 ng/ml, p = 0.024, respectively). Finally, the ROC analysis showed that serum SP-A, SP-B, and SP-C levels at discharge, seemed to be significant predictors of early relapse. Our conclusion is that serum levels of SPs might be related to disease outcomes in COPD patients.
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页码:201 / 205
页数:4
相关论文
共 60 条
[1]  
Devendra G(2002)Lung surfactant in subacute pulmonary disease Respir Res 3 19-22
[2]  
Spragg RG(2013)Pulmonary surfactants and their role in pathophysiology of lung disorders Indian J Exp Biol 51 5-119
[3]  
Akella A(2010)Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease Annu Rev Med 61 105-102
[4]  
Deshpande SB(2007)Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study BMC Pulm Med 7 13-799
[5]  
Whitsett JA(2013)Value of serum and induced sputum surfactant protein-D in chronic obstructive pulmonary disease Multidiscip Respir Med 8 36-425
[6]  
Wert SE(2009)Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD Eur Respir J 34 95-45
[7]  
Weaver TE(2011)COPD association and repeatability of blood biomarkers in the ECLIPSE cohort Respir Res 12 146-1136
[8]  
Sin DD(2011)Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals Eur Respir J 37 791-848
[9]  
Leung R(2010)Two novel mutations in surfactant protein-C, lung function and obstructive lung disease Respir Med 104 418-284
[10]  
Gan WQ(2010)Altered surfactant protein-A expression in type II pneumocytes in COPD Chest 137 37-1138