In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

被引：0
作者：
Sohyun Ahn
Alexandra L. Joyner
机构：
[1] Skirball Institute of Biomolecular Medicine and Department of Cell Biology,Howard Hughes Medical Institute, Developmental Genetics Program
[2] New York University School of Medicine,Department of Physiology and Neuroscience
[3] National Institute of Child Health and Human Development,Unit on Developmental Neurogenetics, Laboratory of Mammalian Genes and Development
[4] National Institutes of Health,undefined
来源：
Nature | 2005年 / 437卷
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摘要：
The signalling protein sonic hedgehog (Shh) was recently implicated in promoting neurogenesis in the postnatal rodent brain. A new genetic cell fate mapping technique shows that a population of adult neural stem cells that rarely divides can also respond to Shh signalling. These quiescent cells are set aside late in embryogenesis, and then are regulated by Shh signalling to self-renew and to generate multiple cell types over time. Hedgehog signalling is known to be involved in the stem cell biology associated with tissue repair and tumour growth: Shh regulated stem cells could be a factor in such processes.
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页码：894 / 897
页数：3
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