The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin

被引：0
作者：
Maria Carmela Bonaccorsi di Patti
Antimo Cutone
Fabio Polticelli
Luigi Rosa
Maria Stefania Lepanto
Piera Valenti
Giovanni Musci
机构：
[1] Sapienza University,Department of Biochemical Sciences
[2] University of Molise,Department of Biosciences and Territory
[3] University Roma Tre,Department of Sciences
[4] National Institute of Nuclear Physics,Department of Public Health and Infectious Diseases
[5] Sapienza University,undefined
来源：
BioMetals | 2018年 / 31卷
关键词：
Lactoferrin; Ferroportin; Ceruloplasmin; Iron; Homeostasis; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the last 20 years, several new genes and proteins involved in iron metabolism in eukaryotes, particularly related to pathological states both in animal models and in humans have been identified, and we are now starting to unveil at the molecular level the mechanisms of iron absorption, the regulation of iron transport and the homeostatic balancing processes. In this review, we will briefly outline the general scheme of iron metabolism in humans and then focus our attention on the cellular iron export system formed by the permease ferroportin and the ferroxidase ceruloplasmin. We will finally summarize data on the role of the iron binding protein lactoferrin on the regulation of the ferroportin/ceruloplasmin couple and of other proteins involved in iron homeostasis in inflamed human macrophages.
引用
收藏
页码：399 / 414
页数：15
相关论文
共 585 条
[21]  
Sek AC(2005)The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis Cell Metab 114 437-1741
[22]  
Ruwe TA(2009)The molecular basis of hepcidin-resistant hereditary hemochromatosis Blood 60 1735-856
[23]  
Vieth KR(2000)The physiopathological significance of ceruloplasmin. A possible therapeutic approach Biochem Pharmacol 27 843-488
[24]  
Jung G(2014)Lactoferrin differently modulates the inflammatory response in epithelial models mimicking human inflammatory and infectious diseases Biometals 15 577-1266
[25]  
Casu C(2015)M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide BMC Cancer 388 482-296
[26]  
Rivella S(1997)Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 115 1258-234
[27]  
Jormakka M(2005)Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver J Clin Invest 437 293-2266
[28]  
Mackenzie B(2017)The ferroxidase hephaestin but not amyloid precursor protein is required for ferroportin-supported iron efflux from primary hippocampal neurons Cell Mol Neurobiol 586 229-151
[29]  
Ganz T(1998)Requirement of intact human ceruloplasmin for the glutathione-linked peroxidase activity FEBS Lett 80 2263-84
[30]  
Nemeth E(2012)Human lactoferrin suppresses TNF-α -induced intercellular adhesion molecule-1 expression via competition with NF-kB in endothelial cells FEBS Lett 110 125-113
12345678910