The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling

被引:0
作者
Mingyao Huang
Xiaoqin Yu
Qing Wang
Zirong Jiang
Xiaofen Li
Wei Chen
Chuangui Song
机构
[1] Clinical Oncology School of Fujian Medical University,Department of Breast Surgery
[2] Fujian Cancer Hospital,Department of Breast Surgery
[3] Fujian Medical University Union Hospital,Department of Thyroid and Breast Surgery
[4] Ningde Municipal Hospital of Ningde Normal University,Department of Oncology Surgery
[5] Fujian Provincial Hospital,undefined
来源
Cell Communication and Signaling | / 22卷
关键词
Immune checkpoint; CD155/TIGIT; CD8 + T cells; TNBC; Immunotherapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 246 条
  • [1] Liu Y(2023)Advances in immunotherapy for triple-negative breast cancer Mol Cancer 22 145-1350
  • [2] Hu Y(2023)Recent advances in targeted strategies for triple-negative breast cancer J Hematol Oncol 16 100-1342
  • [3] Xue J(2023)Programmed Cell Death Protein 1 (PD-1) and Programmed Cell Death Ligand 1 (PD-L1) Immunotherapy: A Promising Breakthrough in Cancer Therapeutics Cureus 15 e44582-567
  • [4] Li J(2023)Targeting PD-1/PD-L1 in cancer immunotherapy: An effective strategy for treatment of triple-negative breast cancer (TNBC) patients Genes Dis 10 1318-2058
  • [5] Yi J(2023)PD-1/PD-L1 immune checkpoint inhibitors in metastatic triple-negative breast cancer: a systematic review and meta-analysis Front Immunol 14 1206689-6388
  • [6] Bu J(2023)TIGIT, a novel immune checkpoint therapy for melanoma Cell Death Dis 14 466-1439
  • [7] Zhang Z(2023)Diverging prognostic effects of CD155 and CD73 expressions in locally advanced triple-negative breast cancer Front Oncol 13 1165257-777
  • [8] Qiu P(2011)Cutting edge: TIGIT has T cell-intrinsic inhibitory functions J Immunol 186 1338-338
  • [9] Gu X(2003)Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule J Exp Med 198 557-196
  • [10] Zhu S(2015)TIGIT and PD-1 impair tumor antigen-specific CD8(+) T cells in melanoma patients J Clin Invest 125 2046-692