The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity.

被引：63
作者：
Celi F.S. [1 ]
Shuldiner A.R. [1 ]
机构：
[1] University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, Room, 660 West Redwood Street, Baltimore, 21201, MD
来源：
Current Diabetes Reports | 2002年 / 2卷 / 2期
关键词：
Troglitazone; Retinoic Acid Receptor; Thyroid Hormone Receptor; Increase Insulin Sensitivity; Adipose Tissue Mass;
D O I：
10.1007/s11892-002-0078-2
中图分类号：
学科分类号：
摘要：
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which upon activation with various natural and synthetic ligands, stimulates the transcription of genes responsible for growth and differentiation of adipocytes. Furthermore, PPAR gamma is the receptor for the insulin-sensitizing thiazolidinediones, which are commonly used for the treatment of type 2 diabetes. Rare inactivating mutations of the gene encoding PPAR gamma are associated with insulin resistance type 2 diabetes, and hypertension, whereas a rare gain of function mutation causes extreme obesity. A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes. These findings indicate a central role of PPAR gamma in fat cell biology and in the pathophysiology of obesity, diabetes, and insulin resistance.
引用
收藏
页码：179 / 185
页数：6
相关论文
共 174 条
[41]  
Umesono K(2000)The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes Int J Obes Relat Metab Disord 24 391-393
[42]  
Murakami KK(1999)Missense variants in the human peroxisome proliferator-activated receptorgamma2 gene in lean and obese subjects Eur J Endocrinol 141 90-92
[43]  
Thompson CC(1999)Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension Nature 402 880-883
[44]  
Evans RM(1997)Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation Biochem Biophys Res Commun 241 270-274
[45]  
Lapsys NM(1998)A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity Nat Genet 20 284-287
[46]  
Kriketos AD(2000)The PPARgamma2 polymorphism Pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients Horm Metab Res 32 413-416
[47]  
Lim-Fraser M(2001)Pro12Ala polymorphism in the peroxisome proliferator-activated receptorgamma2 gene is associated with increased antilipolytic insulin sensitivity Diabetes 50 876-881
[48]  
Dana SL(2000)The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat Genet 26 76-80
[49]  
Hoener PA(1998)Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) gene with obesity in two Caucasian populations Diabetes 47 1806-1808
[50]  
Bilakovics JM(1999)Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women J Clin Endocrinol Metab 84 3708-3712
12345678910