RASSF1A polymorphism in familial breast cancer

被引：0

作者：

J. Bergqvist

A. Latif

S. A. Roberts

K. D. Hadfield

F. Lalloo

A. Howell

D. G. Evans

W. G. Newman

机构：

[1] University of Manchester,Genetic Medicine, St Mary’s Hospital, Manchester Academic Health Sciences Centre (MAHSC)

[2] University of Manchester,Health Research Methodology Group

[3] Wythenshawe Hospital,The Nightingale Centre & Genesis Prevention Centre

[4] University of Manchester,Department of Medical Oncology, The Christie NHS Foundation Trust Research

来源：

Familial Cancer | 2010年 / 9卷

关键词：

Breast cancer; Familial;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Inactivation or loss of the tumour suppressor Ras associated domain family 1 isoform A (RASSF1A) allele has been described in breast cancer. Recently, a missense polymorphism predicting p.A331S in RASSF1A was associated with an increased risk of breast cancer and early-onset breast cancer in BRCA1 and BRCA2 mutation carriers. We genotyped p.A331S RASSF1A in 854 independent, familial, white breast cancer patients (645 BRCA mutation negative, 119 BRCA1 and 90 BRCA2 positive) and compared the genotype in 331 healthy women. The RASSF1A p.A331S variant was not more common in the familial breast cancer cases than in the controls (P = 0.27). Subset analysis demonstrated no association in the BRCA1 (P = 0.26), BRCA2 (P = 0.16) or BRCA negative (P = 0.30) samples. Hence, the RASSF1A p.A331S polymorphism is not confirmed as a significant germline contributor to familial breast cancer susceptibility.

引用

页码：263 / 265

页数：2

共 31 条

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