pH-responsive swelling behavior, elasticity and molecular characteristics of poly(N,N-dimethylaminoethyl methacrylate) gels at various initial monomer concentrations

被引：0
作者：
Nermin Orakdogen
机构：
[1] Istanbul Technical University,Department of Chemistry
来源：
Polymer Bulletin | 2011年 / 67卷
关键词：
Poly(; ,; -dimethylaminoethyl methacrylate); Gels; Initial monomer concentration; Swelling; Elasticity; pH sensitive phase transition;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The equilibrium swelling degree and the modulus of elasticity of pH-responsive poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) gels prepared at various initial monomer concentrations were investigated both in buffer solutions and in aqueous salt solutions. As pH of the solution is increased, PDMAEMA gels first remain in the swollen state up to pH 7.7, then exhibit pH-sensitive phase transitions at 8.0 in which PDMAEMA gels attain a collapsed state. The swelling kinetic measurements of PDMAEMA gels showed that pH sensitivity of PDMAEMA is quite stable and the swelling process is reproducible in accordance with pH changing. The swelling behavior of PDMAEMA gels was analyzed by Flory-Rehner theory and the results were combined by the results of compression measurements to calculate the molecular characteristics of gels. The resulting pH-responsive PDMAEMA gels were elastic and displayed good swelling behavior both in buffer solutions and in aqueous salt solutions, therefore, they can be used as a kind of carrying material in drug delivery systems.
引用
收藏
页码：1347 / 1366
页数：19
相关论文
共 120 条
[1]  
Gupta P(2002)Hydrogels: from controlled release to pH-responsive drug delivery Drug Discov Today 7 569-579
[2]  
Vermani K(2004)Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery Adv Drug Deliv Rev 56 145-172
[3]  
Garg S(2000)Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions Biomaterials 21 1679-1687
[4]  
Ziaie B(1999)Comparative transfection studies of human ovarian carcinoma cells in vitro, ex vivo and in vivo with poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes J Gene Med 1 156-165
[5]  
Baldi A(2004)Polyion complex micelles of pdna with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy Biomacromolecules 5 2128-2136
[6]  
Lei M(1999)Thermosensitive polymers as carriers for DNA delivery J Controlled Release 60 249-259
[7]  
Gu Y(1998)2-(Dimethylamino) ethyl methacrylate based (co)polymers as gene transfer agents J Controlled Release 53 145-153
[8]  
Siegel RA(1996)Effect of size and serum proteins on transfection efficiency of poly ((2-dimethylamino) ethylmethacrylate)-plasmid nanoparticles Pharm Res 13 1038-1042
[9]  
Traitel T(1995)Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH Nature 373 49-52
[10]  
Cohen Y(1997)Temperature-ınduced phase transition of poly(N,N-dimethylaminoethylmethacrylate-co-acrylamide) J Poly Sci B Polym Phys 35 595-3259
12345678910