SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

[21] Smith DR(2006)Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo Int J Cancer 118 583-592

[22] Strausberg RL(2005)Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis Neuro Oncol 7 436-451

[23] Marie SK(2008)Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer Cancer Sci 99 1341-1347

[24] Shinjo SM(1992)A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture Cytotechnology 8 219-229

[25] Yan H(2010)Epigenetic inactivation and tumor suppressor activity of HAI-2/SPINT2 in gastric cancer Int J Cancer 127 1526-1534

[26] Riggins GJ(2015)Epigenetic silencing of SPINT2 promotes cancer cell motility via HGF-MET pathway activation in melanoma J Investig Dermatol 135 2283-2291

[27] Bigner DD(2009)HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions Int J Cancer 124 1811-1819

[28] Karchin R(2001)Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: implication for anti-invasive role of HAI-2/PB in glioblastoma cells Int J Cancer 93 339-345

[29] Papadopoulos N(2015)Identification of global DNA methylation signatures in glioblastoma-derived cancer stem cells J Genet Genomics 42 355-371

[30] Parmigiani G(2014)DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways Transl Psychiatry 4 e433-27564

[21] Smith DR(2006)Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo Int J Cancer 118 583-592

[22] Strausberg RL(2005)Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis Neuro Oncol 7 436-451

[23] Marie SK(2008)Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer Cancer Sci 99 1341-1347

[24] Shinjo SM(1992)A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture Cytotechnology 8 219-229

[25] Yan H(2010)Epigenetic inactivation and tumor suppressor activity of HAI-2/SPINT2 in gastric cancer Int J Cancer 127 1526-1534

[26] Riggins GJ(2015)Epigenetic silencing of SPINT2 promotes cancer cell motility via HGF-MET pathway activation in melanoma J Investig Dermatol 135 2283-2291

[27] Bigner DD(2009)HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions Int J Cancer 124 1811-1819

[28] Karchin R(2001)Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: implication for anti-invasive role of HAI-2/PB in glioblastoma cells Int J Cancer 93 339-345

[29] Papadopoulos N(2015)Identification of global DNA methylation signatures in glioblastoma-derived cancer stem cells J Genet Genomics 42 355-371

[30] Parmigiani G(2014)DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways Transl Psychiatry 4 e433-27564