Production of p-acetaminophenol by whole-cell catalysis using Escherichia coli overexpressing bacterial aryl acylamidase

被引：0

作者：

Hyeok-Jin Ko

Won-Gi Bang

Kyoung Heon Kim

In-Geol Choi

机构：

[1] College of Life Sciences and Biotechnology,Division of Biotechnology

[2] Korea University,undefined

来源：

Biotechnology Letters | 2012年 / 34卷

关键词：

-Acetaminophenol; Aryl acylamidase; Bioconversion; Whole-cell catalysis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Aryl acylamidase (EC 3.5.1.13, AAA) acts on the amide bond between aryl and acyl groups. Whole cells of Escherichia coli overexpressing a novel bacterial AAA synthesized p-acetaminophenol (p-AAP) from p-aminophenol (p-AP, aryl compound) and acetate (acyl donor). Optimum conditions were pH 5.5 and 35°C with 100 mM p-AP and 600 mM sodium acetate in 100 mM sodium phosphate buffer including 1% (v/v) Triton X-100 for 60 h. 13.1 g p-AAP l−1 was produced with a conversion yield of 87%.

引用

页码：677 / 682

页数：5

共 13 条

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BIOTECHNOLOGY LETTERS, 2012, 34 (04) : 677 - 682
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