Perspectives towards antibiotic resistance: from molecules to population

被引:0
作者
Joon-Hee Lee
机构
[1] Pusan National University,Department of Pharmacy, College of Pharmacy
来源
Journal of Microbiology | 2019年 / 57卷
关键词
antibiotic resistance; tripartite efflux pump; adaptive resistance; herd resistance; persister;
D O I
暂无
中图分类号
学科分类号
摘要
For a long time, antibiotics have been ‘magical weapons’ to combat pathogenic microbes. The success of antibiotics is now greatly threatened by resistance to antibiotics and many scientists have already talked about the coming of the postantibiotic era. This special issue is prepared to understand recent research findings and new concepts about antibiotic resistance. Above all, this special issue explores mechanisms for the generation, selection, and spread of antibiotic resistance, and gives insight into what to target to prevent the development of antibiotic resistance. Just as antibiotics came from the concept of “magic bullet”, a breakthrough will come from a new concept based on a profound understanding of antibiotic resistance.
引用
收藏
页码:181 / 184
页数:3
相关论文
共 92 条
[1]  
Abraham E.P.(1988)An enzyme from bacteria able to destroy penicillin (Reprinted from Nature, Vol 146, P. 837, 1940) Rev. Infect. Dis. 10 677-678
[2]  
Chain E.(2016)The treasure called antibiotics Ann. Ib. Postgrad. Med. 14 56-57
[3]  
Adedeji W.A.(2007)The biological role of death and lysis in biofilm development Nat. Rev. Microbiol. 5 721-726
[4]  
Bayles K.W.(2015)Molecular mechanisms of antibiotic resistance Nat. Rev. Microbiol. 13 42-51
[5]  
Blair J.M.(2004)Self-generated diversity produces “insurance effects” in biofilm communities Proc. Natl. Acad. Sci. USA 101 16630-16635
[6]  
Webber M.A.(2016)Distinguishing between resistance, tolerance and persistence to antibiotic treatment Nat. Rev. Microbiol. 14 320-330
[7]  
Baylay A.J.(2010)Origins and evolution of antibiotic resistance Microbiol. Mol. Biol. Rev. 74 417-433
[8]  
Ogbolu D.O.(2011)Creeping baselines and adaptive resistance to antibiotics Drug Resist. Updat. 14 1-21
[9]  
Piddock L.J.(1928)Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system The significance of pneumococcal types. J. Hyg. 27 113-159
[10]  
Boles B.R.(2019)Embedded biofilm, a new biofilm model based on the embedded growth of bacteria J. Microbiol. 57 185-194