The Taxus genome provides insights into paclitaxel biosynthesis

被引：0
|
作者：
Xingyao Xiong
Junbo Gou
Qinggang Liao
Yanlin Li
Qian Zhou
Guiqi Bi
Chong Li
Ran Du
Xiaotong Wang
Tianshu Sun
Lvjun Guo
Haifei Liang
Pengjun Lu
Yaoyao Wu
Zhonghua Zhang
Dae-Kyun Ro
Yi Shang
Sanwen Huang
Jianbin Yan
机构：
[1] Hunan Agricultural University,College of Horticulture
[2] Chinese Academy of Agricultural Sciences,Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Shenzhen Key Laboratory of Agricultural Synthetic Biology, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultu
[3] Ministry of Education,Engineering Research Center for Horticultural Crop Germplasm Creation and New Variety Breeding
[4] Peng Cheng Laboratory Artificial Intelligence Research Center No. 2,MOE Key Laboratory of Bioinformatics, Tsinghua
[5] Tsinghua University,Peking Joint Center for Life Sciences, School of Life Sciences
[6] Qingdao Agricultural University,College of Horticulture
[7] University of Calgary,Department of Biological Sciences
[8] Yunnan Normal University,The AGISCAAS
来源：
Nature Plants | 2021年 / 7卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinensis var. mairei with a total length of 10.23 gigabases. Taxus shared an ancestral whole-genome duplication with the coniferophyte lineage and underwent distinct transposon evolution. We discovered a unique physical and functional grouping of CYP725As (cytochrome P450) in the Taxus genome for paclitaxel biosynthesis. We also identified a gene cluster for taxadiene biosynthesis, which was formed mainly by gene duplications. This study will facilitate the elucidation of paclitaxel biosynthesis and unleash the biotechnological potential of Taxus.
引用
收藏
页码：1026 / 1036
页数：10
相关论文
共 50 条
  • [21] The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance
    Zhang, Lijun
    Li, Xiuxiu
    Ma, Bin
    Gao, Qiang
    Du, Huilong
    Han, Yuanhuai
    Li, Yan
    Cao, Yinghao
    Qi, Ming
    Zhu, Yaxin
    Lu, Hongwei
    Ma, Mingchuan
    Liu, Longlong
    Zhou, Jianping
    Nan, Chenghu
    Qin, Yongjun
    Wang, Jun
    Cui, Lin
    Liu, Huimin
    Liang, Chengzhi
    Qiao, Zhijun
    MOLECULAR PLANT, 2017, 10 (09) : 1224 - 1237
  • [22] The reference genome sequence of Artemisia argyi provides insights into secondary metabolism biosynthesis
    Gao, Xinqiang
    Ma, Qiang
    Zhang, Xiaomeng
    Wang, Xingyun
    Wang, Nuohan
    Cui, Yupeng
    Li, Shuyan
    Ma, Shengming
    Wang, Hong
    Zhang, Kunpeng
    FRONTIERS IN PLANT SCIENCE, 2024, 15
  • [23] The Diesel Tree Sindora glabra Genome Provides Insights Into the Evolution of Oleoresin Biosynthesis
    Yu, Niu
    Sun, Haixi
    Yang, Jinchang
    Li, Rongsheng
    FRONTIERS IN PLANT SCIENCE, 2022, 12
  • [24] The chromosome-level Stevia genome provides insights into steviol glycoside biosynthesis
    Xu, Xiaoyang
    Yuan, Haiyan
    Yu, Xiaqing
    Huang, Suzhen
    Sun, Yuming
    Zhang, Ting
    Liu, Qingquan
    Tong, Haiying
    Zhang, Yongxia
    Wang, Yinjie
    Liu, Chunxiao
    Wu, Lei
    Hou, Menglan
    Yang, Yongheng
    HORTICULTURE RESEARCH, 2021, 8 (01)
  • [25] Genome of Lindera glauca provides insights into the evolution of biosynthesis genes for aromatic compounds
    Xiong, Biao
    Zhang, Limei
    Xie, Lun
    Li, Linzhu
    He, Xiangxiang
    Niu, Yan
    Zhang, Tianyuan
    Liao, Shuai
    Dong, Shubin
    Zhang, Zhixiang
    ISCIENCE, 2022, 25 (08)
  • [26] The chromosome-level genome of Centella asiatica provides insights into triterpenoid biosynthesis
    Wang, Yue
    Huang, Ding
    Luo, Jiajia
    Yao, Shaochang
    Chen, Jianhua
    Li, Liangbo
    Geng, Jingjing
    Mo, Yanlan
    Ming, Ruhong
    Liu, Jihong
    PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2025, 222
  • [27] The wild allotetraploid sesame genome provides novel insights into evolution and lignan biosynthesis
    Wang, Xiao
    Wang, Sen
    Lin, Qiang
    Lu, Jianjun
    Lv, Shiyou
    Zhang, Yanxin
    Wang, Xuefang
    Fan, Wei
    Liu, Wanfei
    Zhang, Liangxiao
    Zhang, Xiurong
    You, Jun
    Cui, Peng
    Li, Peiwu
    JOURNAL OF ADVANCED RESEARCH, 2023, 50 : 13 - 24
  • [28] Chromosome-level genome of Entada phaseoloides provides insights into genome evolution and biosynthesis of triterpenoid saponins
    Lin, Min
    Jian, Jian-Bo
    Zhou, Zhu-Qing
    Chen, Chun-Hai
    Wang, Wen
    Xiong, Hui
    Mei, Zhi-Nan
    MOLECULAR ECOLOGY RESOURCES, 2022, 22 (08) : 3049 - 3067
  • [29] The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids
    Dong, Shanshan
    Liu, Min
    Liu, Yang
    Chen, Fei
    Yang, Ting
    Chen, Lu
    Zhang, Xingtan
    Guo, Xing
    Fang, Dongming
    Li, Linzhou
    Deng, Tian
    Yao, Zhangxiu
    Lang, Xiaoan
    Gong, Yiqing
    Wu, Ernest
    Wang, Yaling
    Shen, Yamei
    Gong, Xun
    Liu, Huan
    Zhang, Shouzhou
    HORTICULTURE RESEARCH, 2021, 8 (01)
  • [30] Chromosome-level genome assembly of Gynostemma pentaphyllum provides insights into gypenoside biosynthesis
    Huang, Ding
    Ming, Ruhong
    Xu, Shiqiang
    Wang, Jihua
    Yao, Shaochang
    Li, Liangbo
    Huang, Rongshao
    Tan, Yong
    DNA RESEARCH, 2021, 28 (05) : 1 - 9
12345