The Taxus genome provides insights into paclitaxel biosynthesis

被引：0
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作者：
Xingyao Xiong
Junbo Gou
Qinggang Liao
Yanlin Li
Qian Zhou
Guiqi Bi
Chong Li
Ran Du
Xiaotong Wang
Tianshu Sun
Lvjun Guo
Haifei Liang
Pengjun Lu
Yaoyao Wu
Zhonghua Zhang
Dae-Kyun Ro
Yi Shang
Sanwen Huang
Jianbin Yan
机构：
[1] Hunan Agricultural University,College of Horticulture
[2] Chinese Academy of Agricultural Sciences,Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Shenzhen Key Laboratory of Agricultural Synthetic Biology, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultu
[3] Ministry of Education,Engineering Research Center for Horticultural Crop Germplasm Creation and New Variety Breeding
[4] Peng Cheng Laboratory Artificial Intelligence Research Center No. 2,MOE Key Laboratory of Bioinformatics, Tsinghua
[5] Tsinghua University,Peking Joint Center for Life Sciences, School of Life Sciences
[6] Qingdao Agricultural University,College of Horticulture
[7] University of Calgary,Department of Biological Sciences
[8] Yunnan Normal University,The AGISCAAS
来源：
Nature Plants | 2021年 / 7卷
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摘要：
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinensis var. mairei with a total length of 10.23 gigabases. Taxus shared an ancestral whole-genome duplication with the coniferophyte lineage and underwent distinct transposon evolution. We discovered a unique physical and functional grouping of CYP725As (cytochrome P450) in the Taxus genome for paclitaxel biosynthesis. We also identified a gene cluster for taxadiene biosynthesis, which was formed mainly by gene duplications. This study will facilitate the elucidation of paclitaxel biosynthesis and unleash the biotechnological potential of Taxus.
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页码：1026 / 1036
页数：10
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