Histone Modification Patterns and Their Responses to Environment

被引：0
作者：
Dai H. [1 ]
Wang Z. [1 ,2 ,3 ]
机构：
[1] Laboratory of Human Environmental Epigenomes, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
[2] The Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, MD
[3] School of Medicine, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, 21205, MD
来源：
Current Environmental Health Reports | 2014年 / 1卷 / 1期
基金：
美国食品与农业研究所;
关键词：
ChIP-seq; Environmental factors; Gene transcription; Histone acetylation; Histone code; Histone methylation; Histone modification patterns;
D O I：
10.1007/s40572-013-0008-2
中图分类号：
学科分类号：
摘要：
Histone modifications play important roles in the epigenetic regulation of gene expression. Recent genome-wide profiling of histone modifications with deep sequencing-based methods provides novel insights of crosstalk between histone modifications, leading to recent proposals of histone “language” or “web” as an alternative of “code” to appreciate combinatorial modification patterns. Environmental factor–altered histone modifications now may be addressed dynamically and systematically with the recognition and use of these interesting combinatorial patterns. © 2014, Springer International Publishing AG.
引用
收藏
页码：11 / 21
页数：10
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