The MOBILIZE Boston Study: Design and methods of a prospective cohort study of novel risk factors for falls in an older population

被引：107
作者：
Leveille S.G. [1 ,2 ]
Kiel D.P. [2 ,3 ]
Jones R.N. [2 ,3 ]
Roman A. [5 ]
Hannan M.T. [2 ,3 ]
Sorond F.A. [2 ,6 ]
Kang H.G. [2 ,3 ]
Samelson E.J. [2 ,3 ]
Gagnon M. [3 ]
Freeman M. [3 ]
Lipsitz L.A. [2 ,3 ,4 ]
机构：
[1] Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA
[2] Harvard Medical School, Boston, MA
[3] Institute for Aging Research, Hebrew SeniorLife, Boston, MA
[4] Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA
[5] University of Massachusetts Boston, Center for Survey Research, Boston, MA
[6] Department of Neurology, Brigham and Women's Hospital, Boston, MA
来源：
BMC Geriatrics | / 8卷 / 1期
关键词：
Cerebral Blood Flow; Hallux Valgus; Short Physical Performance Battery; Brief Pain Inventory; Plantar Fasciitis;
D O I：
10.1186/1471-2318-8-16
中图分类号：
学科分类号：
摘要：
Background. Falls are the sixth leading cause of death in elderly people in the U.S. Despite progress in understanding risk factors for falls, many suspected risk factors have not been adequately studied. Putative risk factors for falls such as pain, reductions in cerebral blood flow, somatosensory deficits, and foot disorders are poorly understood, in part because they pose measurement challenges, particularly for large observational studies. Methods. The MOBILIZE Boston Study (MBS), an NIA-funded Program Project, is a prospective cohort study of a unique set of risk factors for falls in seniors in the Boston area. Using a door-to-door population-based recruitment, we have enrolled 765 persons aged 70 and older. The baseline assessment was conducted in 2 segments: a 3-hour home interview followed within 4 weeks by a 3-hour clinic examination. Measures included pain, cerebral hemodynamics, and foot disorders as well as established fall risk factors. For the falls follow-up, participants return fall calendar postcards to the research center at the end of each month. Reports of falls are followed-up with a telephone interview to assess circumstances and consequences of each fall. A second assessment is performed 18 months following baseline. Results. Of the 2382 who met all eligibility criteria at the door, 1616 (67.8%) agreed to participate and were referred to the research center for further screening. The primary reason for ineligibility was inability to communicate in English. Results from the first 600 participants showed that participants are largely representative of seniors in the Boston area in terms of age, sex, race and Hispanic ethnicity. The average age of study participants was 77.9 years (s.d. 5.5) and nearly two-thirds were women. The study cohort was 78% white and 17% black. Many participants (39%) reported having fallen at least once in the year before baseline. Conclusion. Our results demonstrate the feasibility of conducting comprehensive assessments, including rigorous physiologic measurements, in a diverse population of older adults to study non-traditional risk factors for falls and disability. The MBS will provide an important new data resource for examining novel risk factors for falls and mobility problems in the older population. © 2008 Leveille et al; licensee BioMed Central Ltd.
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[1]  
Close J.C., Lord S.L., Menz H.B., Sherrington C., What is the role of falls?, Best Practice & Research, 19, 6, pp. 913-935, (2005)
[2]  
Rubenstein L.Z., Falls in older people: Epidemiology, risk factors and strategies for prevention, Age and Ageing, 35, SUPPL. 2, (2006)
[3]  
Tinetti M.E., Clinical practice. Preventing falls in elderly persons, N Engl J Med, 348, 1, pp. 42-49, (2003)
[4]  
Wagner E.H., Lacroix A.Z., Grothaus L., Leveille S.G., Hecht J.A., Artz K., Odle K., Buchner D.M., Preventing disability and falls in older adults: A population-based randomized trial, American Journal of Public Health, 84, 11, pp. 1800-1806, (1994)
[5]  
Ganz D.A., Bao Y., Shekelle P.G., Rubenstein L.Z., Will my patient fall?, JAMA, 297, 1, pp. 77-86, (2007)
[6]  
Freedman V.A., Hodgson N., Lynn J., Spillman B.C., Waidmann T., Wilkinson A.M., Wolf D.A., Promoting declines in the prevalence of late-life disability: Comparisons of three potentially high-impact interventions, The Milbank Quarterly, 84, 3, pp. 493-520, (2006)
[7]  
Tinetti M.E., Inouye S.K., Gill T.M., Doucette J.T., Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes, JAMA, 273, 17, pp. 1348-1353, (1995)
[8]  
Leveille S.G., Bean J., Bandeen-Roche K., Jones R., Hochberg M., Guralnik J.M., Musculoskeletal pain and risk for falls in older disabled women living in the community, Journal of the American Geriatrics Society, 50, 4, pp. 671-678, (2002)
[9]  
Leveille S.G., Ling S., Hochberg M.C., Resnick H.E., Bandeen-Roche K.J., Won A., Guralnik J.M., Widespread musculoskeletal pain and the progression of disability in older disabled women, Annals of Internal Medicine, 135, 12, pp. 1038-1046, (2001)
[10]  
Scudds R.J., Robertson J.M., Pain factors associated with physical disability in a sample of community-dwelling senior citizens, J Gerontol a Biol Sci Med Sci, 55, 7, pp. 93-9, (2000)
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