Epidemiology of colorectal polyps

被引：46

作者：

Giacosa A. ^{[1
]}

Frascio F. ^{[1
]}

Munizzi F. ^{[1
]}

机构：

[1] Gastroenterol., Endoscopy Nutr. U., National Cancer Research Institute, Genoa

来源：

Techniques in Coloproctology | 2004年 / 8卷 / Suppl 2期

关键词：

Colon; Epidemiology; Polyps;

D O I：

10.1007/s10151-004-0169-y

中图分类号：

学科分类号：

摘要：

The prevalence of colorectal adenomatous polyps varies widely from country to country. Among asymptomatic, average-risk patients, adenoma prevalence averages approximately 10% in sigmoidoscopy studies and more than 25% in colonoscopy studies, whereas the prevalence of colorectal cancer among these patients is less than 1%. These data may change in the future due to the advent of new technological approaches and, in particular, chromo- and magnifying endoscopy as well as confocal laser endoscopy. The cumulative incidence of new adenomas within 3 years after normal endoscopy averages about 7% by flexible sigmoidoscopy and 27% by colonoscopy. As far as risk factors for colorectal adenomas are concerned, several data are now available on the potential role of various diet items. Tobacco smoking may be important in the early stages of adenoma formation, but not necessarily in the later stages. Alcohol consumption elevates the risk of adenomatous colorectal polyps and this seems increased by ADH3 polymorphism. Another gene-environment relationship of interest in colorectal tumorigenesis may be based on folate's effects on K-ras mutations.

引用

页码：S243 / S247

页数：4

共 13 条

[1]

Neugut A.I., Jacobson J.S., Rella V.A., Prevalence and incidence of colorectal adenomas and cancer in asymptomatic persons, Gastrointest Endosc Clin N Am, 7, pp. 387-399, (1997)

[2]

Imperiale T.F., Wagner D.R., Lin C.Y., Larkin G.N., Rogge J.D., Ransohoff D.F., Results of screening colonoscopy among persons 40 to 49 years of age, N Engl J Med, 346, pp. 1781-1785, (2002)

[3]

Dave S., Hui S., Kroenke K., Imperiale T.F., Is the distal hyperplastic polyp a marker for proximal neoplasia?, J Gen Intern Med, 18, pp. 128-137, (2003)

[4]

Lieberman D.A., Prindiville S., Weiss D.G., Willett W., Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals, JAMA, 290, pp. 2959-2967, (2003)

[5]

Tiemersma E.W., Wark P.A., Ocke M.C., Bunschoten A., Otten M.H., Kok F.J., Kampman E., Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas, Cancer Epidemiol Biomarkers Prev, 12, pp. 419-425, (2003)

[6]

Almendingen K., Hofstad B., Vatn M.H., Lifestyle-related factors and colorectal polyps: Preliminary results from a Norwegian follow-up and intervention study, Eur J Cancer Prev, 11, pp. 153-158, (2002)

[7]

Chen J., Giovannucci E.L., Hunter D.J., MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: An example of gene-environment interactions in colorectal tumorigenesis, J Nutr, 129, 2 SUPPL., pp. 560-564, (1999)

[8]

Martinez M.E., Maltzman T., Marshall J.R., Et al., Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas, Cancer Res, 59, pp. 5181-5185, (1999)

[9]

Young G.P., Rozen P., Levin B., Prevention and Early Detection of Colorectal Cancer, (1996)

[10]

Kiesslich R., Jung M., DiSario J.A., Galle P.R., Neurath M.F., Perspectives of chromo and magnifying endoscopy: How, how much, when, and whom should we stain?, J Clin Gastroenterol, 38, pp. 7-13, (2004)

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