ADAPT-NMR 3.0: utilization of BEST-type triple-resonance NMR experiments to accelerate the process of data collection and assignment

被引：0
作者：
Hesam Dashti
Marco Tonelli
John L. Markley
机构：
[1] University of Wisconsin-Madison,National Magnetic Resonance Facility at Madison, Biochemistry Department
来源：
Journal of Biomolecular NMR | 2015年 / 62卷
关键词：
Automated chemical shift assignments; Bayesian NMR data acquisition; BEST-type experiments; Non-uniform sampling;
D O I：
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学科分类号：
摘要：
ADAPT-NMR (Assignment-directed Data collection Algorithm utilizing a Probabilistic Toolkit in NMR) is a software package whose Bayesian core uses on-the-fly chemical shift assignments to guide data acquisition by non-uniform sampling from a panel of through-bond NMR experiments. The new version of ADAPT-NMR (ADAPT-NMR v3.0) has the option of utilizing 2D tilted-plane versions of 3D fast spectral acquisition with BEST-type pulse sequences, while also retaining the capability of acquiring and processing data from tilted-plane versions of conventional sensitivity-enhanced experiments. The use of BEST experiments significantly reduces data collection times and leads to enhanced performance by ADAPT-NMR.
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页码：247 / 252
页数：5
相关论文
共 86 条
[1]  
Atreya HS(2004)G-matrix Fourier transform NMR spectroscopy for complete protein resonance assignment Proc Natl Acad Sci USA 5 e1000307-77
[2]  
Szyperski T(2009)Probabilistic interaction network of evidence algorithm and its application to complete labeling of peak lists from protein NMR spectroscopy PLoS Comput Biol 7 e33173-138
[3]  
Bahrami A(2012)Robust, integrated computational control of NMR experiments to achieve optimal assignment by ADAPT-NMR PLoS One 73 69-211
[4]  
Assadi AH(1987)Exponential sampling, an alternative method for sampling in two-dimensional NMR experiments J Magn Reson 26 131-12536
[5]  
Markley JL(1993)Methodological advances in protein NMR Accounts Chem Res 178 206-345
[6]  
Eghbalnia HR(2006)Cooling overall spin temperature: protein NMR experiments optimized for longitudinal relaxation effects J Magn Reson 127 12528-9217
[7]  
Bahrami A(2005)High-resolution iterative frequency identification for NMR as a general strategy for multidimensional data collection J Am Chem Soc 9 336-10881
[8]  
Tonelli M(2006)Single-scan multidimensional NMR Cr Chim 125 9204-717
[9]  
Sahu SC(2003)Principles and features of single-scan two-dimensional NMR spectroscopy J Am Chem Soc 102 10876-148
[10]  
Singarapu KK(2005)Automated projection spectroscopy (APSY) Proc Natl Acad Sci 47 708-5559
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