Hepatic encephalopathy [Hepatische fnzephalopathie]

被引：0
作者：
Kircheis G. [1 ,2 ]
机构：
[1] Klinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine-Universität Düsseldorf
[2] Klinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf
来源：
Der Gastroenterologe | 2007年 / 2卷 / 4期
关键词：
Astrocyte swelling; Critical flicker frequency; Hepatic Encephalopathy; Oscillatory networks; Psychometric tests; Treatment precipitating factors;
D O I：
10.1007/s11377-007-0088-3
中图分类号：
学科分类号：
摘要：
Hepatic encephalopathy (HE) is a neuropsychiatric disorder which can appear as a complication of acute or chronic liver disorders. Pathophysiologically the disorder is a clinical manifestation of a low-grade chronic cerebral edema, which leads to changes in astrocytic function with disturbances of glioneuronal communication. The findings point to a disturbance of cerebral oscillatory networks in HE that is triggered by possible neurotoxic- and hydration-sensitive, thalamic structures and results in an abnormally low-frequency and rigid thalamocortical and corticomuscular coupling. While the diagnosis of high-grade HE will be done exclusively by the clinical picture, psychometric and neurophysiological tests are necessary to diagnose the low-grade forms. Yet, the analysis of the critical flicker frequency (CFF) has been shown to be an easy and simple semi-quantitative test procedure for the quantification and follow-up of neuropsychiatric deficits in HE. The recognition and consequent treatment of the precipitating factors are the most important therapeutic measures. These are complemented by dietetic and pharmaceutical treatment.. © Springer Medizin Verlag 2007.
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页码：251 / 260
页数：9
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