Hepatic encephalopathy [Hepatische fnzephalopathie]

被引：0

作者：

Kircheis G. ^{[1
,2
]}

机构：

[1] Klinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine-Universität Düsseldorf

[2] Klinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf

来源：

Der Gastroenterologe | 2007年 / 2卷 / 4期

关键词：

Astrocyte swelling; Critical flicker frequency; Hepatic Encephalopathy; Oscillatory networks; Psychometric tests; Treatment precipitating factors;

D O I：

10.1007/s11377-007-0088-3

中图分类号：

学科分类号：

摘要：

Hepatic encephalopathy (HE) is a neuropsychiatric disorder which can appear as a complication of acute or chronic liver disorders. Pathophysiologically the disorder is a clinical manifestation of a low-grade chronic cerebral edema, which leads to changes in astrocytic function with disturbances of glioneuronal communication. The findings point to a disturbance of cerebral oscillatory networks in HE that is triggered by possible neurotoxic- and hydration-sensitive, thalamic structures and results in an abnormally low-frequency and rigid thalamocortical and corticomuscular coupling. While the diagnosis of high-grade HE will be done exclusively by the clinical picture, psychometric and neurophysiological tests are necessary to diagnose the low-grade forms. Yet, the analysis of the critical flicker frequency (CFF) has been shown to be an easy and simple semi-quantitative test procedure for the quantification and follow-up of neuropsychiatric deficits in HE. The recognition and consequent treatment of the precipitating factors are the most important therapeutic measures. These are complemented by dietetic and pharmaceutical treatment.. © Springer Medizin Verlag 2007.

引用

页码：251 / 260

页数：9

共 30 条

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