Effect of Short-Term and Chronic Caffeine Intake on Rats with Various Anxiety Level

被引:0
作者
S. K. Sudakov
O. F. Medvedeva
I. V. Rusakova
I. B. Figurina
机构
[1] Ministry of Health,Laboratory of Neurobiology of Craving, Research Center of Addiction
来源
Bulletin of Experimental Biology and Medicine | 2001年 / 132卷
关键词
caffeine; emotionality; inbred rats; social isolation;
D O I
暂无
中图分类号
学科分类号
摘要
Effect of one-day and chronic (3 week) drinking of 0.1% caffeine as a single source of fluid on anxiety in rats with different anxiety level (either genetically determined or individually acquired) was studied. When housed in groups, Fisher-344 rats had a significantly higher anxiety level than WAG/G rats. When the rats were housed individually, their anxiety gradually increased. The effect of short-term and chronic intake of caffeine in high doses depended on both genetically determined sensitivity to this agent and environmental factors (social isolation). It was concluded that chronic caffeine drinking does not induce persistent emotional changes similar to drug abuse, because caffeine withdrawal produced little effect on animal anxiety.
引用
收藏
页码:1177 / 1179
页数:2
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