Blood Manganese Concentration is Elevated in Infants with Iron Deficiency

被引:0
作者
Sangkyu Park
Chang-Sun Sim
Heun Lee
Yangho Kim
机构
[1] University of Ulsan College of Medicine,Department of Pediatrics, Ulsan University Hospital
[2] University of Ulsan College of Medicine,Department of Occupational and Environmental Medicine, Ulsan University Hospital
来源
Biological Trace Element Research | 2013年 / 155卷
关键词
Iron; Deficiency; Manganese; Anemia;
D O I
暂无
中图分类号
学科分类号
摘要
The present study was done to determine whether blood Mn concentration is elevated in iron-deficient infants. Thirty-one infants with iron deficiency and thirty-six control subjects (6–24 months of age) were tested for blood Mn concentration, complete blood counts, serum ferritin, and serum iron/transferring iron-binding capacity (Fe/TIBC). All the 31 iron-deficient infants were treated with iron supplement; however, 19 of them underwent blood Mn checkup again in compliance with follow-up schedule when their ferritin levels returned to the normal range. Iron therapies were done for 1–6 months (mean, 2.8; standard deviation, 1.6) using ferric hydroxide-polymaltose complex (6 mg/kg Fe3+ daily). Infants with iron deficiency had a higher mean blood Mn concentration than controls (2.550 vs. 1.499 μg/dL, respectively). After iron therapy, the blood Mn levels of iron-deficient infants significantly decreased compared to their pre-therapy levels (2.045 vs. 2.971 μg/dL, respectively), and their hemoglobin and ferritin levels significantly increased. After adjustment for covariates (e.g., age and breast-feeding), multiple linear regression models showed that increased blood Mn levels were significantly associated with low serum ferritin and hemoglobin levels, whereas with Fe/TIBC there was only a tendency. Our results indicate that iron deficiency increases blood Mn levels in infants, presumably by increasing Mn absorption.
引用
收藏
页码:184 / 189
页数:5
相关论文
共 156 条
[1]  
Barbeau A(1976)Role of manganese in dystonia Adv Neurol 14 339-352
[2]  
Inoue N(1994)Manganism and idiopathic Parkinson's disease: similarities and differences Neurology 44 1583-1586
[3]  
Cloutier T(2004)Mn-induced parkinsonism and Parkinson's disease Ann N Y Acad Sci 1012 209-223
[4]  
Calne DB(2012)Toxic encephalopathy Saf Health Work 3 243-256
[5]  
Chu NS(2013)Manganese neurotoxicity: a focus on glutamate transporters Ann Occup Environ Med 25 4-11
[6]  
Huang CC(2013)Prenatal exposures to environmental chemicals and children's neurodevelopment: an update Saf Health Work 4 1-439
[7]  
Lu CS(2010)Early postnatal blood manganese levels and children's neurodevelopment Epidemiology 21 433-143
[8]  
Olanow W(2011)Intellectual impairment in school-age children exposed to manganese from drinking water Environ Health Perspect 119 138-127
[9]  
Olanow CW(2007)Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water Environ Health Perspect 115 122-1506
[10]  
Kim Y(2011)Manganese exposure from drinking water and children's classroom behavior in Bangladesh Environ Health Perspect 119 1501-875