Role of NF-κB in the pathogenesis of diabetes and its associated complications

被引：0
作者：
Sandip Patel
Dev Santani
机构：
[1] New Vallabh Vidyanagar,Department of Pharmacology, Indukaka Ipcowala College of Pharmacy
[2] Rofel Shri G.M. Bilakhia College of Pharmacy,Department of Clinical Pharmacy
来源：
Pharmacological Reports | 2009年 / 61卷
关键词：
NF-κB; diabetes; diabetic cardiomyopathy; diabetic retinopathy; diabetic nephropathy; diabetic neuropathy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The nuclear factor-κB (NF-κB) family is comprised of DNA-binding protein factors that are required for the transcription of most proinflammatory molecules, including adhesion molecules, enzymes, cytokines, and chemokines. Studies performed in a variety of cell and animal based experimental systems suggest that NF-κB activation is a key event early in the pathobiology of diabetes. The purpose of this review is to summarize the current knowledge about the molecular biology of NF-κB and to review evidence that implicates NF-κB in the pathogenesis of diabetes and its associated complications.
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页码：595 / 603
页数：8
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