Cytotoxic prenylated flavones from Artocarpus champeden

被引：0
作者：
Yana M. Syah
Lia D. Juliawaty
Sjamsul A. Achmad
Euis H. Hakim
Emilio L. Ghisalberti
机构：
[1] Bandung Institute of Technology,Natural Products Research Group, Department of Chemisty
[2] The University of Western Australia,Department of Chemistry, School of Biomedical and Chemical Sciences
来源：
Journal of Natural Medicines | 2006年 / 60卷
关键词：
Spreng; Moraceae; Prenylated flavones; Artoindonesianin A-2 and A-3; Cytotoxicity;
D O I：
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中图分类号：
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摘要：
Two new prenylated flavones, artoindonesianins A-2 (1) and A-3 (2), together with three known prenylated flavones, artonin B (3), heterophyllin (4) and cudraflavone C (5), have been isolated and identified from the chloroform extract of the heartwood of Artocarpus champeden. The structures of these compounds were determined on the basis of spectroscopic data, including UV, IR, 1-D and 2-D NMR, and mass spectra. The cytotoxic properties of the new compounds, together with three prenylated flavones isolated previously, artoindonesianins Q (6), R (7) and T (8), were evaluated against murine leukemia P-388 cells. Based on their IC50 values, compounds 1, 2, 4, 5 and 8 showed strong cytotoxic properties.
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页码：308 / 312
页数：4
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Nomura T(undefined) (Moraceae) undefined undefined undefined-undefined
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