Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals

被引：22

作者：

Grigoryan G.A. ^{[1
]}

Pavlova I.V. ^{[1
]}

Zaichenko M.I. ^{[1
]}

机构：

[1] Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow

来源：

Neuroscience and Behavioral Physiology | 2022年 / 52卷 / 5期

关键词：

anxiety and depression-like behavior; elevated plus maze; forced swimming; open field; social isolation; stress; sucrose preference test;

D O I：

10.1007/s11055-022-01297-1

中图分类号：

学科分类号：

摘要：

This review describes the role of social isolation in the development of anxiety and depression-like behavior in rodents. The duration of social isolation, age from onset of social isolation, sex, species, and strain of animals, the nature of the model used, and other factors have been shown to have influences. The molecular-cellular mechanisms of development of anxiety and depression-like behavior under the influence of social isolation and the roles of the HHAS, oxidative and nitrosative stress, neuroinflammation, BDNF, neurogenesis, synaptic plasticity, as well as monoamines in these mechanisms are discussed. This review presents data on sex differences in the effects of social isolation, along with the effects of interactions with other types of stress, and the roles of an enriched environment and other factors in ameliorating the negative sequelae of social isolation. © 2022, Springer Nature Switzerland AG.

引用

页码：722 / 738

页数：16

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