Antagonistic effect of divalent cations Ca2+ and Mg2+ on the morphological development of Streptomyces hygroscopicus var. geldanus

被引：0
作者：
Lynne F. Dobson
Daniel G. O’Shea
机构：
[1] Dublin City University,Bioprocess Engineering Research Group, School of Biotechnology
来源：
Applied Microbiology and Biotechnology | 2008年 / 81卷
关键词：
Calcium; Geldanamycin; Hydrophobicity; Magnesium; Morphology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Supplementation of the divalent cations calcium and magnesium to submerged cultures of Streptomyces hygroscopicus var. geldanus greatly influenced morphological development and secondary metabolite synthesis. The disparate response could be explained in terms of the differential effects of Ca2+ and Mg2+ ions on cell surface hydrophobicity. Cultures supplemented with calcium ions were found to be hydrophobic, which resulted in cell concentration-dependent aggregation. In contrast, those grown in a magnesium-rich medium were found to be hydrophilic with the organism growing as freely dispersed filaments that synthesised geldanamycin at an optimal rate in comparison to hydrophobic pellets.
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页码：119 / 126
页数：7
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