The role of endocytosis in activating and regulating signal transduction

被引：0
作者：
Emma R. Andersson
机构：
[1] Karolinska Institute,Department of Cell and Molecular Biology
来源：
Cellular and Molecular Life Sciences | 2012年 / 69卷
关键词：
Endocytosis; Clathrin; Dynamin; Caveolin; Primary cilium; Signaling; Wnt; Notch; Eph; Ephrin; EGF;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Endocytosis is increasingly understood to play crucial roles in most signaling pathways, from determining which signaling components are activated, to how the signal is subsequently transduced and/or terminated. Whether a receptor-ligand complex is internalized via a clathrin-dependent or clathrin-independent endocytic route, and the complexes’ subsequent trafficking through specific endocytic compartments, to then be recycled or degraded, has profound effects on signaling output. This review discusses the roles of endocytosis in three markedly different signaling pathways: the Wnt, Notch, and Eph/Ephrin pathways. These offer fundamentally different signaling systems: (1) diffusible ligands inducing signaling in one cell, (2) membrane-tethered ligands inducing signaling in a contacting receptor cell, and (3) bi-directional receptor-ligand signaling in two contacting cells. In each of these systems, endocytosis controls signaling in fascinating ways, and comparison of their similarities and dissimilarities will help to expand our understanding of endocytic control of signal transduction across multiple signaling pathways.
引用
收藏
页码：1755 / 1771
页数：16
相关论文
共 986 条
  • [1] Doherty GJ(2009)Mechanisms of endocytosis Annu Rev Biochem 78 857-902
  • [2] McMahon HT(1996)Control of EGF receptor signaling by clathrin-mediated endocytosis Science 274 2086-2089
  • [3] Vieira AV(2005)Clathrin-independent endocytosis of ubiquitinated cargos Proc Natl Acad Sci USA 102 2760-2765
  • [4] Lamaze C(2001)Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Science 293 2449-2452
  • [5] Schmid SL(2001)Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities J Biol Chem 276 21425-21433
  • [6] Sigismund S(2000)Caveolin-3 deficiency causes muscle degeneration in mice Hum Mol Genet 9 3047-3054
  • [7] Woelk T(2001)Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J Biol Chem 276 38121-38138
  • [8] Puri C(2002)Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae Mol Cell Biol 22 2329-2344
  • [9] Maspero E(2010)Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling Biochim Biophys Acta 1803 983-989
  • [10] Tacchetti C(2003)Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover Nat Cell Biol 5 410-421
12345678910