A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

被引：0
作者：
Melissa R. Warden
Aslihan Selimbeyoglu
Julie J. Mirzabekov
Maisie Lo
Kimberly R. Thompson
Sung-Yon Kim
Avishek Adhikari
Kay M. Tye
Loren M. Frank
Karl Deisseroth
机构：
[1] Stanford University,Department of Bioengineering
[2] Neurosciences Program,Department of Brain & Cognitive Sciences
[3] Stanford University,Department of Physiology
[4] Bio-X Program,Department of Psychiatry & Behavioral Sciences
[5] Stanford University,undefined
[6] Picower Institute for Learning & Memory,undefined
[7] Massachusetts Institute of Technology,undefined
[8] University of California San Francisco,undefined
[9] W.M. Keck Center for Integrative Neuroscience,undefined
[10] University of California San Francisco,undefined
[11] Stanford University,undefined
[12] CNC Program,undefined
[13] Stanford University,undefined
[14] Howard Hughes Medical Institute,undefined
[15] Stanford University,undefined
来源：
Nature | 2012年 / 492卷
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学科分类号：
摘要：
High-speed tracking of effortful responses and neuronal activity in rats during a forced swim test identifies medial prefrontal cortex (mPFC) neurons that respond during escape-related swimming but not normal locomotion, and optogenetics shows that mPFC neurons projecting to the brainstem dorsal raphe nucleus, which is implicated in depression, modulate this behavioural response to challenge
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页码：428 / 432
页数：4
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