Immunostimulation using granulocyte- and granulocyte-macrophage colony stimulating factor in patients with severe sepsis and septic shock

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作者
Joerg C Schefold
机构
[1] University Medicine Berlin,Department of Nephrology and Intensive Care Medicine, Charité Campus Virchow Clinic
来源
Critical Care | / 15卷
关键词
Severe Sepsis; Phagocytotic Activity; Cytokine Expression Profile; Nosocomial Infection Rate; Expression Profile Change;
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摘要
Sepsis is associated with failure of multiple organs, including failure of the immune system. The resulting 'sepsis-associated immunosuppression' resembles a state of immunological anergy that is characterized by repeated 'infectious hits', prolonged multiple-organ failure, and death. As a consequence, adjunctive treatment approaches using measures of immunostimulation with colony-stimulating factors (CSFs) were tested in animal experiments and clinical trials. Herein, data from randomized clinical trials will be discussed in the context of a recently published meta-analysis investigating the effects of granulocyte- and granulocyte-macrophage colony-stimulating factor therapy in patients with severe sepsis and septic shock.
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