TRPA1 underlies a sensing mechanism for O2

被引：0
|
作者：
Nobuaki Takahashi
Tomoyuki Kuwaki
Shigeki Kiyonaka
Tomohiro Numata
Daisuke Kozai
Yusuke Mizuno
Shinichiro Yamamoto
Shinji Naito
Ellen Knevels
Peter Carmeliet
Toru Oga
Shuji Kaneko
Seiji Suga
Toshiki Nokami
Jun-ichi Yoshida
Yasuo Mori
机构：
[1] Graduate School of Engineering,Department of Synthetic Chemistry and Biological Chemistry
[2] Kyoto University,Department of Technology and Ecology
[3] Hall of Global Environmental Studies,Department of Physiology
[4] Kyoto University,Division of Pathology
[5] Advanced Biomedical Engineering Research Unit,Department of Respiratory Care and Sleep Control Medicine
[6] Kyoto University,Department of Molecular Pharmacology
[7] Graduate School of Medical and Dental Sciences,undefined
[8] Kagoshima University,undefined
[9] Core Research for Evolutional Science and Technology,undefined
[10] Japan Science and Technology Agency,undefined
[11] National Ureshino Hospital,undefined
[12] Vesalius Research Center,undefined
[13] Catholic University of Leuven,undefined
[14] Vesalius Research Center,undefined
[15] Flanders Institute for Biotechnology,undefined
[16] Graduate School of Medicine,undefined
[17] Kyoto University,undefined
[18] Graduate School of Pharmaceutical Sciences,undefined
[19] Kyoto University,undefined
来源：
Nature Chemical Biology | 2011年 / 7卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The redox-sensitive TRP channel TRPA1 is activated in hyperoxic and hypoxic conditions directly through modification of cysteine residues by O2 and indirectly through prolyl hydroxylation by PHDs, enzymes related to the hypoxia-inducible factor HIF-1, thus helping to explain how O2 is sensed by sensory and vagal neurons.[graphic not available: see fulltext]
引用
收藏
页码：701 / 711
页数：10
相关论文
共 50 条
  • [1] TRPA1 underlies a sensing mechanism for O2
    Takahashi, Nobuaki
    Kuwaki, Tomoyuki
    Kiyonaka, Shigeki
    Numata, Tomohiro
    Kozai, Daisuke
    Mizuno, Yusuke
    Yamamoto, Shinichiro
    Naito, Shinji
    Knevels, Ellen
    Carmeliet, Peter
    Oga, Toru
    Kaneko, Shuji
    Suga, Seiji
    Nokami, Toshiki
    Yoshida, Jun-ichi
    Mori, Yasuo
    NATURE CHEMICAL BIOLOGY, 2011, 7 (10) : 701 - 711
  • [2] Sensing of O2 by TRPA1 channels
    Mori, Yasuo
    Kozai, Daisuke
    Takahashi, Nobuaki
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63 : S39 - S39
  • [3] TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing
    Mori, Yasuo
    Takahashi, Nobuaki
    Kurokawa, Tatsuki
    Kiyonaka, Shigeki
    PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 2017, 93 (07): : 464 - 482
  • [4] The O2-sensing TRPA1 channel regulates mitochondrial activities
    Hamano, Satoshi
    Takahashi, Nobuaki
    Ebert, Maximilian
    ReikoSakaguchi
    Semba, Hiroaki
    Suzuki, Jyunji
    Iino, Masamitsu
    Takeda, Norihiko
    Mori, Yasuo
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015, 128 (03) : S178 - S178
  • [5] O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses
    Uchiyama, Makoto
    Nakao, Akito
    Kurita, Yuki
    Fukushi, Isato
    Takeda, Kotaro
    Numata, Tomohiro
    Tran, Ha Nam
    Sawamura, Seishiro
    Ebert, Maximilian
    Kurokawa, Tatsuki
    Sakaguchi, Reiko
    Stokes, Alexander J.
    Takahashi, Nobuaki
    Okada, Yasumasa
    Mori, Yasuo
    CURRENT BIOLOGY, 2020, 30 (17) : 3378 - +
  • [6] A role for TRPA1 in O2-sensing of lung epithelial and endothelial cells?
    Kannler, M.
    Gudermann, T.
    Steinritz, D.
    Dietrich, A.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2017, 390 : S39 - S39
  • [7] TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex
    Kawabata, Ryo
    Shimoyama, Shuji
    Ueno, Shinya
    Yao, Ikuko
    Arata, Akiko
    Koga, Kohei
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [8] TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex
    Ryo Kawabata
    Shuji Shimoyama
    Shinya Ueno
    Ikuko Yao
    Akiko Arata
    Kohei Koga
    Scientific Reports, 13
  • [9] Chemical sensing properties of Takifugu TRPA1
    Oda, Mai
    Ninomiya, Kazuya
    Kurogi, Mako
    Saitoh, Osamu
    NEUROREPORT, 2015, 26 (15) : 908 - 914
  • [10] The TRPA1 channel in migraine mechanism and treatment
    Benemei, S.
    Fusi, C.
    Trevisan, Gabriela
    Geppetti, Pierangelo
    BRITISH JOURNAL OF PHARMACOLOGY, 2014, 171 (10) : 2552 - 2567
12345