STLV-1 as a model for studying HTLV-1 infection

被引：0
作者：
Brice Jégado
Fatah Kashanchi
Hélène Dutartre
Renaud Mahieux
机构：
[1] Ecole Normale Supérieure de Lyon,International Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111
[2] Université Lyon, Université Claude Bernard Lyon 1, CNRS, UMR5308
[3] Fondation pour la Recherche Médicale,Laboratory of Molecular Virology
[4] Labex Ecofect,undefined
[5] George Mason University,undefined
来源：
Retrovirology | / 16卷
关键词：
HTLV-1; STLV-1; ATL; Prevalence; Interspecies transmission; Animal model; Therapy;
D O I：
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摘要：
Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As HTLV-1, STLV-1 is the etiological agent of ATL, while no case of TSP/HAM has been described. Given its similarities with HTLV-1, STLV-1 represents a unique tool used for performing clinical studies, vaccine studies as well as basic science.
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