Dynamic protein assembly by programmable DNA strand displacement

被引：0
|
作者：
Rebecca P. Chen
Daniel Blackstock
Qing Sun
Wilfred Chen
机构：
[1] University of Delaware,Department of Chemical and Biomolecular Engineering
来源：
Nature Chemistry | 2018年 / 10卷
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D O I：
暂无
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学科分类号：
摘要：
The construction of dynamic protein–DNA nano-assemblies suitable for modulating protein proximities and activities has now been demonstrated. This approach uses DNA strand displacement and can enable control of enzyme activity to be programmed using logic gates. As a demonstration, a split enzyme capable of activating a prodrug is triggered is by cancer-specific miRNAs.
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页码：474 / 481
页数：7
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