Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine

被引：0
作者：
Silvia Sookoian
Carlos J. Pirola
机构：
[1] University of Buenos Aires-National Council of Scientific and Technological Research (CONICET),Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari
[2] University of Buenos Aires-National-Council of Scientific and Technological Research (CONICET),IDIM
[3] Instituto de Investigaciones Médicas A. Lanari-IDIM CONICET,Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari
来源：
Current Diabetes Reports | 2013年 / 13卷
关键词：
Epigenetics; DNA methylation; Fatty liver; NASH; PPARGC1A; PGC1a; Insulin resistance; Mitochondria; Histones; Acetylation; Deacetylation; Hypoxia; Translational medicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this article, we review the current knowledge of and recent insights into the role of epigenetic factors in the development of insulin resistance (IR), with emphasis on peroxisome proliferator-activated receptor gamma coactivator 1α (PPARGC1A or PGC1α) methylation on fetal programming and liver modulation of glucose-related phenotypes. We discuss the pathogenesis of IR beyond the integrity of β-cell function and illustrate the novel concept of mitochondrial epigenetics to explain the pathobiology of metabolic-syndrome-related phenotypes. Moreover, we discuss whether epigenetic marks in genes of the circadian rhythm system are able to modulate insulin/glucose-related metabolic functions and place hypoxia inducible factor 1 α (HIF1α) as a part of the master CLOCK gene/protein interaction network that might modulate IR. Finally, we highlight relevant information about epigenetic marks and IR so that clinicians practicing in the community may envision future areas of medical intervention and predict putative biomarkers for early disease detection.
引用
收藏
页码：229 / 237
页数：8
相关论文
共 241 条
[21]  
Willett WC(2011)DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age Epigenetics 6 171-22
[22]  
Rimm EB(2010)Reprogramming of human umbilical cord stromal mesenchymal stem cells for myogenic differentiation and muscle repair Stem Cell Rev 6 512-9
[23]  
Godfrey KM(2009)Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns Obesity (Silver Spring) 17 1032-9
[24]  
Barker DJ(2006)Mitochondrial DNA depletion in small- and large-for-gestational-age newborns Obesity (Silver Spring) 14 2193-80
[25]  
Hales CN(2012)Placental adiponectin gene DNA methylation levels are associated with mothers’ blood glucose concentration Diabetes 61 1272-41
[26]  
Barker DJ(2010)Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy Diabetes Care 33 2436-9
[27]  
Clark PM(2010)Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth Am J Physiol Gastrointest Liver Physiol 299 G1023-17
[28]  
Hales CN(2011)Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats J Physiol 589 2707-102
[29]  
Barker DJ(2008)Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome J Mol Endocrinol 41 91-26
[30]  
Harder T(2011)Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates FASEB J 25 714-49
12345678910