Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine

被引:0
作者
Silvia Sookoian
Carlos J. Pirola
机构
[1] University of Buenos Aires-National Council of Scientific and Technological Research (CONICET),Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari
[2] University of Buenos Aires-National-Council of Scientific and Technological Research (CONICET),IDIM
[3] Instituto de Investigaciones Médicas A. Lanari-IDIM CONICET,Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari
来源
Current Diabetes Reports | 2013年 / 13卷
关键词
Epigenetics; DNA methylation; Fatty liver; NASH; PPARGC1A; PGC1a; Insulin resistance; Mitochondria; Histones; Acetylation; Deacetylation; Hypoxia; Translational medicine;
D O I
暂无
中图分类号
学科分类号
摘要
In this article, we review the current knowledge of and recent insights into the role of epigenetic factors in the development of insulin resistance (IR), with emphasis on peroxisome proliferator-activated receptor gamma coactivator 1α (PPARGC1A or PGC1α) methylation on fetal programming and liver modulation of glucose-related phenotypes. We discuss the pathogenesis of IR beyond the integrity of β-cell function and illustrate the novel concept of mitochondrial epigenetics to explain the pathobiology of metabolic-syndrome-related phenotypes. Moreover, we discuss whether epigenetic marks in genes of the circadian rhythm system are able to modulate insulin/glucose-related metabolic functions and place hypoxia inducible factor 1 α (HIF1α) as a part of the master CLOCK gene/protein interaction network that might modulate IR. Finally, we highlight relevant information about epigenetic marks and IR so that clinicians practicing in the community may envision future areas of medical intervention and predict putative biomarkers for early disease detection.
引用
收藏
页码:229 / 237
页数:8
相关论文
共 241 条
[1]  
Reaven GM(1988)Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 1595-607
[2]  
Dastani Z(2012)Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals PLoS Genet 8 e1002607-69
[3]  
Hivert MF(2012)A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance Nat Genet 44 659-34
[4]  
Timpson N(2011)Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes Diabetes 60 2624-89
[5]  
Manning AK(2010)Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis Nat Genet 42 579-16
[6]  
Hivert MF(2010)New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 105-84
[7]  
Scott RA(2010)The genetics of insulin resistance: where’s Waldo? Curr Diab Rep 10 476-55
[8]  
Strawbridge RJ(2012)Genetic risk factors for type 2 diabetes: insights from the emerging genomic evidence Curr Vasc Pharmacol 10 147-50
[9]  
Dupuis J(1996)Birth weight and adult hypertension, diabetes mellitus, and obesity in US men Circulation 94 3246-24
[10]  
Prokopenko I(2001)Fetal programming and adult health Public Health Nutr 4 611-22