Comparison of HBV reactivation between patients with high HBV-DNA and low HBV-DNA loads undergoing PD-1 inhibitor and concurrent antiviral prophylaxis

被引:2
作者
Min-Ke He
Chuan Peng
Yang Zhao
Run-Bin Liang
Zhi-Cheng Lai
Anna Kan
Qi-Jiong Li
Wei Wei
Yao-Jun Zhang
Min-Shan Chen
Rong-Ping Guo
Ming Shi
机构
[1] Collaborative Innovation Center for Cancer Medicine,Department of Hepatobiliary Oncology, Sun Yat
[2] Collaborative Innovation Center for Cancer Medicine,Sen University Cancer Center, State Key Laboratory of Oncology in South China
来源
Cancer Immunology, Immunotherapy | 2021年 / 70卷
关键词
Hepatocellular carcinoma; Programmed cell death protein-1 inhibitor; Antiviral prophylaxis; Hepatitis B virus reactivation; Hepatic arterial infusion chemotherapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
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页码:3207 / 3216
页数:9
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[1]  
Park JW(2016)Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study JAMA Oncol 3 524-548
[2]  
Chen M(2015)Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE study Liver Int 35 2155-2166
[3]  
Colombo M(2013)Roles played by chemolipiodolization and embolization in chemoembolization for hepatocellular carcinoma: single-blind, randomized trial J Natl Cancer Inst 105 59-68
[4]  
Shi M(2018)Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial Lancet Oncol 19 940-952
[5]  
Lu LG(2017)Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial Lancet 389 2492-2502
[6]  
Fang WQ(2019)LBA38_PRCheckMate 459: a randomized, multi-center phase III study of nivolumab (NIVO) vs sorafenib (SOR) as first-line (1L) treatment in patients (pts) with advanced hepatocellular carcinoma (aHCC) Ann Oncol 30 874-875
[7]  
Zhu AX(2009)PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV J Clin Invest 119 551-564
[8]  
Finn RS(2008)PD-1 and its ligands in tolerance and immunity Annu Rev Immunol 26 677-704
[9]  
Edeline J(2010)PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection J Viral Hepat 17 453-458
[10]  
El-Khoueiry AB(2017)Programmed cell death 1 (PD-1) and cytotoxic t lymphocyte-associated antigen 4 (CTLA-4) in viral hepatitis Int J Mol Sci 18 1517-1207