Giant nonfunctioning adrenocortical carcinoma: A case report and review of the literature

被引：5

作者：

Almarzouq A. ^{[1
]}

Asfar S. ^{[2
]}

Hussain S. ^{[3
]}

Al-Hunayan A. ^{[4
]}

Aldousari S. ^{[4
]}

机构：

[1] Urology Unit, Department of Surgery, Mubarak Alkabeer Hospital, Kuwait City

[2] Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait City

[3] Department of Pathology, Mubarak Alkabeer Hospital, Kuwait City

[4] Urology Unit, Department of Surgery, Faculty of Medicine, Kuwait University, PO Box 24923, Safat

来源：

BMC Research Notes | / 7卷 / 1期

关键词：

Adrenocortical carcinoma; Adrenocortical mass; Giant; Nonfunctioning;

D O I：

10.1186/1756-0500-7-769

中图分类号：

学科分类号：

摘要：

Background: Adrenocortical carcinoma is a rare and aggressive malignancy. Patients usually present early with manifestation of abnormal hormone secretion. However, adrenocortical carcinoma can also be nonfunctioning, and such patients present late with a mass effect or distant metastases. Case presentation: We herein report a case of a 30-year-old Sri-Lankan woman who presented with a 3-month history of left flank pain associated with nausea, vomiting, and weight loss. Imaging revealed a large left upper quadrant mass with a 1.8-cm left lung nodule. The differential diagnoses included a left adrenal mass, left upper pole renal mass, and retroperitoneal sarcoma. A functional adrenal work-up revealed no abnormal findings. Surgical excision of the mass was uneventful with no postoperative complications. Pathological analysis revealed a nonfunctioning adrenocortical carcinoma measuring 16 × 14 × 10 cm. To our knowledge, a mass of this size is among the largest nonfunctioning adrenocortical carcinomas reported in the published literature. The investigations and approach to treatment were consistent with those in the published literature. Conclusion: Large nonfunctioning adrenocortical carcinomas pose a diagnostic and therapeutic challenge, and most are diagnosed at a late stage. Appropriate imaging and functional work-up of the mass are vital before treatment. Surgical excision is safe, even for large adrenocortical carcinomas; excision in patients with advanced disease has been shown to have the best outcomes. © 2014 Almarzouq et al.; licensee BioMed Central Ltd.

引用

共 16 条

[1]

Norton J.A., Adrenal tumors, Cancer: Principles and Practice of Oncology, pp. 1528-1539, (2005)

[2]

Icard P., Goudet P., Charpenay C., Andreassian B., Carnaille B., Chapuis Y., Cougard P., Henry J.F., Proye C., Adrenocortical carcinomas: Surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons Study Group, World J Surg, 25, pp. 891-897, (2001)

[3]

Kopf D., Goretzki P.E., Lehnert H., Clinical management of malignant adrenal tumors, J Canc Res Clin Oncol, 127, 3, pp. 143-155, (2001)

[4]

Gaujoux S., Al-Ahmadie H., Allen P.J., Gonen M., Shia J., Dangelica M., Dematteo R., Fong Y., Jamagin W.R., Resection of adrenocortical carcinoma liver metastasis: Is it justified?, Ann Surg Oncol, 19, (2012)

[5]

Kemp C., Ripley R., Mathur A., Steinburg S.M., Nguyen D.M., Fojo T., Schrump D.S., Pulmonary resection for metastatic adrenocortical carcinoma: The national cancer institute experience, Ann Thorac Surg, 92, 4, pp. 1195-1200, (2011)

[6]

Vassilopoulou-Sellin R., Schultz P.N., Adrenocortical carcinoma. Clinical outcome at the end of the 20th century, Cancer, 92, (2001)

[7]

Ayala-Ramirez M., Jasim S., Feng L., Ejaz S., Deniz F., Busaidy N., Waguespack S.G., Naing A., Sircar K., Wood C.G., Pagliaro L., Jimenez C., Vassilopoulou-Sellin R., Hebra M.A., Adrenocortical Carcinoma: Clinical Outcomes and prognosis of 330 Patients at a Tertiary Care Center, Eur J Endocrinol, 169, pp. 891-899, (2013)

[8]

Schulick R.D., Brennan M.F., Long-term survival after complete resection and repeat resection in patients with adrenocortical carcinoma, Ann Surg Oncol, 6, pp. 719-726, (1999)

[9]

Schteingart D.E., Doherty G.M., Gauger P.G., Giordano T.J., Hammer G.D., Korobkin M., Worden F.P., Management of patients with adrenal cancer: Recommendations of an international consensus conference, Endocr Relat Cancer, 12, (2005)

[10]

Norton J., Le H., Adrenal tumors, Cancer, pp. 1770-1785, (2001)

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