Lessons from next-generation sequencing analysis in hematological malignancies

被引：0
作者：
E Braggio
J B Egan
R Fonseca
A K Stewart
机构：
[1] Mayo Clinic in Arizona,
来源：
Blood Cancer Journal | 2013年 / 3卷
关键词：
hematological malignancy; genome sequencing; RNA sequencing; clonal architecture;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.
引用
收藏
页码：e127 / e127
相关论文
共 496 条
  • [1] Lander ES(2001)Initial sequencing and analysis of the human genome Nature 409 860-921
  • [2] Linton LM(2008)DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome Nature 456 66-72
  • [3] Birren B(2010)DNMT3A mutations in acute myeloid leukemia N Engl J Med 363 2424-2433
  • [4] Nusbaum C(2011)Studying the epigenome using next generation sequencing J Med Genet 48 721-730
  • [5] Zody MC(2011)The next generation: using new sequencing technologies to analyse gene regulation Respirology 16 210-222
  • [6] Baldwin J(2009)Massively parallel sequencing: the next big thing in genetic medicine Am J Hum Genet 85 142-154
  • [7] Ley TJ(2011)Whole cancer genome sequencing by next-generation methods Am J Clin Pathol 136 527-539
  • [8] Mardis ER(2009)RNA-Seq: a revolutionary tool for transcriptomics Nat Rev Genet 10 57-63
  • [9] Ding L(2009)ChIP-seq: advantages and challenges of a maturing technology Nat Rev Genet 10 669-680
  • [10] Fulton B(2010)Sequencing technologies—the next generation Nat Rev Genet 11 31-46
12345678910