Lessons from next-generation sequencing analysis in hematological malignancies

被引：0
作者：
E Braggio
J B Egan
R Fonseca
A K Stewart
机构：
[1] Mayo Clinic in Arizona,
来源：
Blood Cancer Journal | 2013年 / 3卷
关键词：
hematological malignancy; genome sequencing; RNA sequencing; clonal architecture;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.
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页码：e127 / e127
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