Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones

被引：0
作者：
N. V. Tursunova
V. N. Syrov
Z. A. Khushbaktova
Yu. V. Tornuev
M. G. Klinnikova
机构：
[1] Federal Research Center of Fundamental and Translational Medicine,Institute of Molecular Pathology and Pathomorphology
[2] Academy of Sciences of the Republic of Uzbekistan,Institute of Chemistry of Plant Substances
来源：
Bulletin of Experimental Biology and Medicine | 2021年 / 172卷
关键词：
toxic hepatitis; liver microsomes; cytochrome P-450; nitric oxide system, sesquiterpene lactones;
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学科分类号：
摘要：
We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl4-induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.
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页码：133 / 136
页数：3
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共 56 条
[1]  
Rodnova YA(2013)Hypolipidemic effect leucomisine model of acute hyperlipidemia induced by ethanol Byull. Sib. Med. 12 43-48
[2]  
Ivanov VV(2013)Activity and nitrergicheskoy monooxygenase in liver microsomes systems under the influence of body inducers and inhibitors drug metabolism Vrach-Aspirant. 59 73-78
[3]  
Ledyukova SI(2016)Role of nitric oxide in processes of free radical oxidation Vestn. Ross. Voen.-Med. Akad. 1 228-233
[4]  
Chuchalin VS(2002)Effect of the total sesquiterpenoid extract from Pharm. Chem. J. 36 91-93
[5]  
Ratkin AV(2015) on cholepoietic processes in rat liver in the normal state and during experimental hepatitis Trends Pharmacol. Sci. 36 524-536
[6]  
Rakhimova BB(2020)Nitric oxide in liver diseases Drug Metab. Rev. 52 455-471
[7]  
Khabarov IA(2017)Regulation of cytochrome P450 enzyme activity and expression by nitric oxide in the context of inflammatory disease Front. Pharmacol. 8 202-159
[8]  
Adekenov SM(2016)Exploring the Role of CYP3A4 mediated drug metabolism in the pharmacological modulation of nitric oxide production Toxicol. Sci. 151 150-815
[9]  
Sayfullaeva SA(2005)Selective targeting of heme protein in cytochrome P450 and nitric oxide synthase by diphenyleneiodonium Free Radic. Res. 39 797-1663
[10]  
Sattarov IS(2013)Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids Mol. Biol. Rep. 40 1655-undefined
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