Biomarkers in anal cancer: from biological understanding to stratified treatment

被引：0
作者：
Christopher M Jones
Vicky Goh
David Sebag-Montefiore
Duncan C Gilbert
机构：
[1] Leeds Cancer Centre,Division of Imaging Sciences and Biomedical Engineering
[2] Leeds Teaching Hospitals NHS Trust,Department of Radiology
[3] Leeds Institute of Cancer & Pathology,undefined
[4] University of Leeds,undefined
[5] King's College London,undefined
[6] Guy's and St Thomas' NHS Foundation Trust,undefined
[7] Sussex Cancer Centre,undefined
[8] Royal Sussex County Hospital,undefined
来源：
British Journal of Cancer | 2017年 / 116卷
关键词：
anal cancer; chemoradiotherapy; HPV; squamous cell carcinoma of the anus; human papilloma virus; biomarkers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with oncogenic subtypes of human papilloma virus and this plays a significant role in their sensitivity to treatment. However, not all tumours are cured with CRT and there remain opportunities to improve outcomes in terms of oncological control and also reducing late toxicities. Understanding the biology of ASCC promises to allow a more personalised approach to treatment, with the development and validation of a range of biomarkers and associated techniques that are the focus of this review.
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页码：156 / 162
页数：6
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