Use of tuberculin skin test for assessment of immune recovery among previously malnourished children in Ethiopia

被引：7
作者：
Bahwere P. [1 ,2 ]
James P. [1 ,3 ]
Abdissa A. [4 ]
Getu Y. [5 ]
Getnet Y. [5 ]
Sadler K. [1 ]
Girma T. [6 ]
机构：
[1] Valid International, 35, Leopold Street, Oxford
[2] Research Centre in Epidemiology, Biostatistics and Clinical Research, School of Public Health, Free University of Brussels, Brussels
[3] London School of Hygiene and Tropical Medicine, London
[4] Department of Medical, Laboratory Sciences and Pathology, Jimma University, Jimma, Oromia
[5] Save Children Federation, Addis Ababa
[6] Department of Paediatrics and Child Health, Jimma University, Jimma, Oromia
来源：
BMC Research Notes | / 10卷 / 1期
关键词：
Community-based management of acute malnutrition; Delayed-type hypersensitivity response; Immunity; Morbidity; Severe acute malnutrition; Tuberculin purified protein derivative; Tuberculin skin test;
D O I：
10.1186/s13104-017-2909-x
中图分类号：
学科分类号：
摘要：
Objective: To compare levels of immunity in children recovering from severe acute malnutrition (cases) against those of community controls (controls). Results: At baseline children recovering from severe acute malnutrition had lower, mid upper arm circumference (122 mm for cases and 135 mm for controls; p < 0.001), weight-for-height Z-score (- 1.0 for cases and - 0.5 for controls; p < 0.001), weight-for-age Z-score (- 2.8 for cases and - 1.1 for controls; p < 0.001) and height/length-for-age Z-score (- 3.6 for cases and - 1.4 for controls; p < 0.001), than controls. Age and gender matched community controls. At baseline, prevalence of a positive tuberculin skin test, assessed by cutaneous delayed-type hypersensitivity reaction skin test, was very low in both cases (3/93 = 3.2%) and controls (2/94 = 2.1%) and did not significantly increase at 6 months follow up (6/86 = 7.0% in cases and 3/84 = 3.4% in controls). The incidences of common childhood morbidities, namely fever, diarrhoea and cough, were 1.7-1.8 times higher among cases than controls. In conclusion, these results show that tuberculin skin test does not enable any conclusive statements regarding the immune status of patients following treatment for severe acute malnutrition. The increased incidence of infection in cases compared to controls suggests persistence of lower resistance to infection even after anthropometric recovery is achieved. © 2017 The Author(s).
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