Transport, Uptake, and Metabolism of the Bis(pivaloyloxymethyl)-Ester Prodrug of 9-(2- Phosphonylmethoxyethyl)Adenine in an In Vitro Cell Culture System of the Intestinal Mucosa (Caco-2)

被引：0
作者：
Pieter Annaert
Renaat Kinget
Lieve Naesens
Erik de Clercq
Patrick Augustijns
机构：
[1] Campus Gasthuisberg,Laboratory of Galenical and Clinical Pharmacy
[2] KULeuven,undefined
[3] Rega Institute for Medical Research,undefined
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
Caco-2; prodrug; intestinal permeability; intestinal metabolism; bis(POM)-PMEA; antiviral;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To evaluate intestinal transport, uptake and metabolism characteristics of the bis(pivaloyloxymethyl)-ester [bis(POM)-ester] of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA].
引用
收藏
页码：492 / 496
页数：4
相关论文
共 61 条
  • [1] Naesens L.(1994)undefined Rev. Med. Virol. 4 147-159
  • [2] Balzarini J.(1996)undefined Antimicrob. Agents Chemother. 40 22-28
  • [3] De Clercq E.(1994)undefined Pharm. Res. 11 839-843
  • [4] Naesens L.(1991)undefined AIDS 5 21-28
  • [5] Balzarini J.(1994)undefined Antimicrob. Agents Chemother. 38 365-368
  • [6] Bischofberger N.(1994)undefined J. Med. Chem. 37 1857-1864
  • [7] De Clercq E.(1993)undefined Pharm. Res. 10 S294-2250
  • [8] Cundy K. C.(1993)undefined Antimicrob. Agents Chemother. 37 2247-749
  • [9] Fishback J. A.(1995)undefined Antiviral Res. 26 A229-275
  • [10] Shaw J.-P.(1989)undefined Gastroenterology 96 736-2283
1234567